Trial reportTranslational psychiatry2015
Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.
Trial report in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Acute effects of oxytocin in music performance anxiety: a crossover, randomized, placebo-controlled trial.Psychopharmacology · 2020Trial
- The role of oxytocin on self-serving lying.Brain and behavior · 2020Trial
- Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification.Neurobiology of aging · 2019Trial
- Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.PloS one · 2018Trial
- A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets.Molecular psychiatry · 2026Article
- The Promise of Intranasal Oxytocin in Treating Borderline Personality Disorder: A Narrative Review.Brain sciences · 2025Review
- The Role of Oxytocin in Alzheimer's Disease and Its Relationship with Social Interaction.Cells · 2023Review
- Review
- The Comprehensive Neural Mechanism of Oxytocin in Analgesia.Current neuropharmacology · 2022Review
- The Importance of Experimental Investigation of the CNS Oxytocin System.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism.Scientific reports · 2021Article
- Most oxytocin administration studies are statistically underpowered to reliably detect (or reject) a wide range of effect sizes.Comprehensive psychoneuroendocrinology · 2020Article
- Oxytocin and the stress buffering effect of social company: a genetic study in daily life.Social cognitive and affective neuroscience · 2020Article
- Oxytocin and Three Kinds of Dangerous Behaviors in a Romantic Relationship: Playing, Suffering, and Stalking.Frontiers in psychiatry · 2020Article
- [Oxytocin in schizophrenia : Evidence for an etiological and therapeutic relevance of the social neuromodulator].Der Nervenarzt · 2019Review
- Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.Social cognitive and affective neuroscience · 2018Article
- TheFrontiers in psychiatry · 2018Article
- Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2017Article
- Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism.Molecular psychiatry · 2017Article
- Social Decision-Making and the Brain: A Comparative Perspective.Trends in cognitive sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intranasal administration of the neuropeptide oxytocin has been shown to influence a range of complex social cognitions and social behaviors, and it holds therapeutic potential for the treatment of mental disorders characterized by social functioning deficits such as autism, social phobia and borderline personality disorder. However, considerable variability exists in individual responses to oxytocin administration. Here, we undertook a study to investigate the role of genetic variation in sensitivity to exogenous oxytocin using a socioemotional task. In a randomized, double-blind, placebo-controlled experiment with a repeated-measures (crossover) design, we assessed the performance of 203 men on an emotion recognition task under oxytocin and placebo. We took a haplotype-based approach to investigate the association between oxytocin receptor gene variation and oxytocin sensitivity. We identified a six-marker haplotype block spanning the promoter region and intron 3 that was significantly associated with our measure of oxytocin sensitivity. Specifically, the TTCGGG haplotype comprising single-nucleotide polymorphisms rs237917-rs2268498-rs4564970-rs237897-rs2268495-rs53576 is associated with increased emotion recognition performance under oxytocin versus placebo, and the CCGAGA haplotype with the opposite pattern. These results on the genetic modulation of sensitivity to oxytocin document a significant source of individual differences with implications for personalized treatment approaches using oxytocin administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.