ReviewHormones and behavior2016
When mothering goes awry: Challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving.
Review in Hormones and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences.BMJ open · 2018Trial
- Maternal Childhood Neglect is Linked to Greater Infant Cortisol Levels and Larger Infant Limbic Volumes.Child maltreatment · 2026Article
- A Cross-Generational Methylomic Signature of Infant Maltreatment in Newborn Rhesus Macaques.Biological psychiatry · 2025Article
- Maternal caregiving moderates relations between maternal childhood maltreatment and infant cortisol regulation.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Is neglect the first form of threat?Attachment & human development · 2025Review
- Article
- Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study.iScience · 2024Article
- Reconsidering the nature of threat in infancy: Integrating animal and human studies on neurobiological effects of infant stress.Neuroscience and biobehavioral reviews · 2024Review
- Alterations in adolescent brain serotonin (5HT)Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Linking maternal disrupted interaction and infant limbic volumes: The role of infant cortisol output.Psychoneuroendocrinology · 2023Article
- Negative versus withdrawn maternal behavior: Differential associations with infant gray and white matter during the first 2 years of life.Human brain mapping · 2023Article
- The developmental consequences of early adverse care on infant macaques: A cross-fostering study.Psychoneuroendocrinology · 2022Article
- Developmental costs associated with early maternal withdrawal.Child development perspectives · 2022Article
- Early life exposure to unpredictable parental sensory signals shapes cognitive development across three species.Frontiers in behavioral neuroscience · 2022Review
- Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications.Frontiers in behavioral neuroscience · 2022Review
- The Neurobiology of Infant Attachment-Trauma and Disruption of Parent-Infant Interactions.Frontiers in behavioral neuroscience · 2022Review
- Postpartum scarcity-adversity disrupts maternal behavior and induces a hypodopaminergic state in the rat dam and adult female offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Advancing the RDoC initiative through the assessment of caregiver social processes.Development and psychopathology · 2021Article
- Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates.Development and psychopathology · 2020Article
- Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving.Development and psychopathology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This article is part of a Special Issue "Parental Care".Across mammalian species, mothers shape socio-emotional development and serve as essential external regulators of infant physiology, brain development, behavior patterns, and emotional regulation. Caregiving quality, consistency and predictability shape the infant's underlying neurobiological processes. Although the requirements for "optimal" caregiving differ across species, the negative long-term consequences of the absence of needed caregiving (e.g. neglect) or the presence of harmful/aversive caregiving (e.g. physical abuse), are translatable across species. Recognizing the significant potential of cross species comparisons in terms of defining underlying mechanisms, effective translation requires consideration of the evolutionary, ecological, and fundamental biological and developmental differences between and among species. This review provides both an overview of several success stories of cross-species translations in relation to negative caregiving and a template for future studies seeking to most effectively define the underlying biological processes and advance research dedicated to mitigating the lasting negative health consequences of child maltreatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.