ArticleeLife2015
Coordination of planar cell polarity pathways through Spiny-legs.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Dachsous-Fat signaling shapes the Drosophila wing through mechanical forces.PLoS biology · 2026Article
- Interactions between the myosin Dachs, the adaptor Dlish, and the palmitoyltransferase Approximated mediate Fat-Dachsous signaling.bioRxiv : the preprint server for biology · 2026Article
- Cell autonomous polarization by the planar cell polarity signaling pathway.Nature communications · 2025Article
- Cell autonomous polarization by the planar cell polarity signaling pathway.bioRxiv : the preprint server for biology · 2025Article
- Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.Development (Cambridge, England) · 2024Article
- Emergence of planar cell polarity from the interplay of local interactions and global gradients.eLife · 2024Article
- Coordination of Cilia Movements in Multi-Ciliated Cells.Journal of developmental biology · 2022Review
- Planar cell polarity: intracellular asymmetry and supracellular gradients of Dachsous.Open biology · 2022Article
- The wing imaginal disc.Genetics · 2022Article
- Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium.Frontiers in cell and developmental biology · 2022Article
- Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins.Frontiers in cell and developmental biology · 2022Review
- Article
- How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?Open biology · 2021Review
- Planar cell polarity in the larval epidermis ofOpen biology · 2020Article
- Planar cell polarity signaling in the development of left-right asymmetry.Current opinion in cell biology · 2020Review
- Article
- Prickle1 is required for EMT and migration of zebrafish cranial neural crest.Developmental biology · 2019Article
- Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Early girl is a novel component of the Fat signaling pathway.PLoS genetics · 2019Article
- Localization of Hippo Signaling Components in Drosophila by Fluorescence and Immunofluorescence.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Morphogenesis and physiology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate cells and their behaviors, but the relationship between PCP systems has been controversial. We have characterized how the Frizzled and Dachsous-Fat PCP systems are connected through the Spiny-legs isoform of the Prickle-Spiny-legs locus. Two different components of the Dachsous-Fat system, Dachsous and Dachs, can each independently interact with Spiny-legs and direct its localization in vivo. Through characterization of the contributions of Prickle, Spiny-legs, Dachsous, Fat, and Dachs to PCP in the Drosophila wing, eye, and abdomen, we define where Dachs-Spiny-legs and Dachsous-Spiny-legs interactions contribute to PCP, and provide a new understanding of the orientation of polarity and the basis of PCP phenotypes. Our results support the direct linkage of PCP systems through Sple in specific locales, while emphasizing that cells can be subject to and must ultimately resolve distinct, competing PCP signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.