ArticleRadiology2016
Intrinsic Resting-State Functional Connectivity in the Human Spinal Cord at 3.0 T.
Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Brain Network Signature of Autoscopic Phenomena in Humans.CNS neuroscience & therapeutics · 2025Article
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spinal fMRI demonstrates segmental organisation of functionally connected networks in the cervical spinal cord: A test-retest reliability study.Human brain mapping · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spinal Cord fMRI: A New Window into the Central Nervous System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Detection of resting-state functional connectivity in the lumbar spinal cord with 3T MRI.Scientific reports · 2023Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources.NeuroImage · 2023Article
- Automated slice-specific z-shimming for functional magnetic resonance imaging of the human spinal cord.Human brain mapping · 2022Article
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- Resting-state brain and spinal cord networks in humans are functionally integrated.PLoS biology · 2020Article
- Intrinsic functional architecture of the non-human primate spinal cord derived from fMRI and electrophysiology.Nature communications · 2019Article
- A practical protocol for measurements of spinal cord functional connectivity.Scientific reports · 2018Article
- Ten Key Insights into the Use of Spinal Cord fMRI.Brain sciences · 2018Review
- Multiple sclerosis lesions affect intrinsic functional connectivity of the spinal cord.Brain : a journal of neurology · 2018Article
- Resting-state functional connectivity in the rat cervical spinal cord at 9.4 T.Magnetic resonance in medicine · 2018Article
- Spinal cord MRI at 7T.NeuroImage · 2018Review
- Investigating resting-state functional connectivity in the cervical spinal cord at 3T.NeuroImage · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo apply resting-state functional magnetic resonance (MR) imaging to map functional connectivity of the human spinal cord. MATERIALS AND
methodsStudies were performed in nine self-declared healthy volunteers with informed consent and institutional review board approval. Resting-state functional MR imaging was performed to map functional connectivity of the human cervical spinal cord from C1 to C4 at 1 × 1 × 3-mm resolution with a 3.0-T clinical MR imaging unit. Independent component analysis (ICA) was performed to derive resting-state functional MR imaging z-score maps rendered on two-dimensional and three-dimensional images. Seed-based analysis was performed for cross validation with ICA networks by using Pearson correlation.
resultsReproducibility analysis of resting-state functional MR imaging maps from four repeated trials in a single participant yielded a mean z score of 6 ± 1 (P < .0001). The centroid coordinates across the four trials deviated by 2 in-plane voxels ± 2 mm (standard deviation) and up to one adjacent image section ± 3 mm. ICA of group resting-state functional MR imaging data revealed prominent functional connectivity patterns within the spinal cord gray matter. There were statistically significant (z score > 3, P < .001) bilateral, unilateral, and intersegmental correlations in the ventral horns, dorsal horns, and central spinal cord gray matter. Three-dimensional surface rendering provided visualization of these components along the length of the spinal cord. Seed-based analysis showed that many ICA components exhibited strong and significant (P < .05) correlations, corroborating the ICA results. Resting-state functional MR imaging connectivity networks are qualitatively consistent with known neuroanatomic and functional structures in the spinal cord.
conclusionResting-state functional MR imaging of the human cervical spinal cord with a 3.0-T clinical MR imaging unit and standard MR imaging protocols and hardware reveals prominent functional connectivity patterns within the spinal cord gray matter, consistent with known functional and anatomic layouts of the spinal cord.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.