ArticleEnvironmental health perspectives2016
In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case-control study in Switzerland and an updated meta-analysis.International archives of occupational and environmental health · 2022Pooled it
- Trial
- Paternal exposure to hydrocarbon solvents in the workplace and cancer risk in children and adolescents.Journal of exposure science & environmental epidemiology · 2026Article
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
- Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Nested ecosystems theory for conceptualizing brain tumors.Disease models & mechanisms · 2026Review
- Establishing environmental causes of childhood cancer: a view from the IARC Monographs.UCL open. Environment · 2026Article
- The association between air pollution exposure and childhood cancer: a scoping review about the challenges in epidemiological studies.BMC public health · 2025Article
- Ambient Toxic Air Contaminants in the Maternal Residential Area during Pregnancy and Cerebral Palsy in the Offspring.Environmental health perspectives · 2025Article
- Public Health Effects of Polycyclic Aromatic Hydrocarbons Exposure Through Air, Water, Soil, and Food in Ghana: Possible Economic Burden.Environmental health insights · 2025Review
- Maternal Exposure to Heavy Metals From Industrial Sources During Pregnancy and Childhood Cancer Risk in California.Journal of occupational and environmental medicine · 2024Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Environmental, social and behavioral risk factors in association with spatial clustering of childhood cancer incidence.Spatial and spatio-temporal epidemiology · 2023Article
- Impacts of Environmental Pollution on Brain Tumorigenesis.International journal of molecular sciences · 2023Review
- 1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2022Review
- Interpreting a standardized and normalized measure of neighborhood socioeconomic status for a better understanding of health differences.Archives of public health = Archives belges de sante publique · 2021Article
- Inequalities in Exposure to Ambient Air Neurotoxicants and Disparities in Markers of Neurodevelopment in Children by Maternal Nativity Status.International journal of environmental research and public health · 2021Article
- Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark: a nationwide register-based case-control study.Cancer causes & control : CCC · 2020Article
- Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations.CA: a cancer journal for clinicians · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about the influence of environmental factors on the etiology of childhood brain tumors.
objectivesWe examined risks for brain tumors in children after prenatal and infant exposure to monitored ambient air toxics.
methodsWe ascertained all cases of medulloblastoma, central nervous system primitive neuroectodermal tumor (PNET), and astrocytoma before 6 years of age diagnosed in 1990-2007 from the California Cancer Registry and selected controls randomly from birth rolls matched by birth year. Exposures to air toxics during pregnancy/infancy for 43 PNET, 34 medulloblastoma, and 106 astrocytoma cases and 30,569 controls living within 5 mi of a monitor were determined. With factor analysis we assessed the correlational structures of 26 probable carcinogenic toxics, and estimated odds ratios by brain tumor type in logistic regression models.
resultsPNETs (≤ 38 cases) were positively associated with interquartile range (IQR) increases in prenatal exposure to acetaldehyde [odds ratio (OR) = 2.30; 95% CI: 1.44, 3.67], 1,3-butadiene (OR = 2.23; 95% CI: 1.28, 3.88), benzene, and toluene; and with IQR increases in exposure during the first year of life to ortho-dichlorobenzene (OR = 3.27; 95% CI: 1.17, 9.14), 1,3-butadiene (OR = 3.15; 95% CI: 1.57, 6.32), and benzene. All exposures except ortho-dichlorobenzene loaded on the same factor. Medulloblastoma (≤ 30 cases) was associated with prenatal exposure to polycyclic aromatic hydrocarbons (PAHs combined: OR = 1.44; 95% CI: 1.15, 1.80). Exposures to lead and some PAHs during the first year of life were positively associated with astrocytoma, but the confidence intervals included the null value (e.g., for lead, OR = 1.40; 95% CI: 0.97, 2.03).
conclusionsOur data suggest that in utero and infancy exposures to air toxics generated by industrial and road traffic sources may increase the risk of PNET and medulloblastoma, with limited support for increased risks for astrocytoma in children up to age 6. CITATION: von Ehrenstein OS, Heck JE, Park AS, Cockburn M, Escobedo L, Ritz B. 2016. In Utero and early-life exposure to ambient air toxics and childhood brain tumors: a population-based case-control study in California, USA. Environ Health Perspect 124:1093-1099; http://dx.doi.org/10.1289/ehp.1408582.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.