ArticleEnvironmental research2015
Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study.
Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Pesticide safe use practice and acute health symptoms, and associated factors among farmers in developing countries: a systematic review and meta-analysis of an epidemiological evidence.BMC public health · 2024Pooled it
- Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review.Environmental health : a global access science source · 2017Pooled it
- Environmental and occupational exposures for chronic kidney disease of unknown aetiology (CKDu): field investigations in rural Sri Lanka.BMC public health · 2026Article
- Toxicological profiling and health hazard characterization of pesticides widely used in Tanzania unmarked.Toxicology reports · 2026Article
- Evidence-Based Assessment of Pesticide-Related Nephrotoxicity: Clinical Outcomes, Experimental Data, and Molecular Signatures.International journal of molecular sciences · 2026Review
- Updating our quantification of non-occupational pesticide exposure in agricultural settings: A revised algorithm for the Agricultural Health Study.Environmental advances · 2026Article
- Comprehensive dose-dependent hepatorenal protective effects ofFrontiers in pharmacology · 2026Article
- Air Pollution, Kidney Injury, and Green Nephrology-Thinking About Its Association and Causation.Journal of clinical medicine · 2025Review
- Article
- Ameliorative impacts of astaxanthin against atrazine-induced renal toxicity through the modulation of ionic homeostasis and Nrf2 signaling pathways in mice.Toxicology research · 2024Article
- Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication.ACS pharmacology & translational science · 2024Review
- Ingested nitrate and nitrite and end-stage renal disease in licensed pesticide applicators and spouses in the Agricultural Health Study.Journal of exposure science & environmental epidemiology · 2024Article
- Non-traditional risk factors of progression of chronic kidney disease in adult population: a scoping review.Frontiers in medicine · 2023Article
- An ecological study regarding the association between paraquat exposure and end stage renal disease.Environmental health : a global access science source · 2022Article
- Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study.International journal of environmental research and public health · 2022Article
- Smartphone-coupled three-layered paper-based microfluidic chips demonstrating stereoscopic capillary-driven fluid transport towards colorimetric detection of pesticides.Analytical and bioanalytical chemistry · 2022Article
- Epidemiology of hospitalizations due to pesticide intoxication-associated acute kidney injury in China.International urology and nephrology · 2022Article
- Prevalence of Pesticide Use and Occupational Exposure Among Small-Scale Farmers in Western Ethiopia.Environmental health insights · 2022Article
- Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.Environment international · 2021Article
- Whose Jurisdiction Is Home Contamination? Para-Occupational 'Take-Home' Herbicide Residue Exposure Risks among Forestry Workers' Families in South Africa.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPesticide exposure has been found to cause renal damage and dysfunction in experimental studies, but epidemiological research on the renal effects of chronic low-level pesticide exposure is limited. We investigated the relationships between end-stage renal disease (ESRD) among wives of licensed pesticide applicators (N=31,142) in the Agricultural Health Study (AHS) and (1) personal pesticide use, (2) exposure to the husband's pesticide use, and (3) other pesticide-associated farming and household activities.
methodsAHS participants reported pesticide exposure via self-administered questionnaires at enrollment (1993-1997). ESRD cases were identified via linkage to the United States Renal Data System. Associations between ESRD and pesticide exposures were estimated with Cox proportional hazard regression models controlling for age at enrollment. Models of associations with farming and household factors were additionally adjusted for personal use of pesticides.
resultsWe identified 98 ESRD cases diagnosed between enrollment and 31 December 2011. Although women who ever applied pesticides (56% of cohort) were less likely than those who did not apply to develop ESRD (Hazard Ratio (HR): 0.42; 95% CI: 0.28, 0.64), among women who did apply pesticides, the rate of ESRD was significantly elevated among those who reported the highest (vs. lowest) cumulative general pesticide use (HR: 4.22; 95% CI: 1.26, 14.20). Among wives who never applied pesticides, ESRD was associated with husbands' ever use of paraquat (HR=1.99; 95% CI: 1.14, 3.47) and butylate (HR=1.71; 95% CI: 1.00, 2.95), with a positive exposure-response pattern for husband's cumulative use of these pesticides.
conclusionsESRD may be associated with direct and/or indirect exposure to pesticides among farm women. Future studies should evaluate indirect exposure risk among other rural populations.
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