ReviewBritish journal of clinical pharmacology2016
Pharmacological treatment of cardiac glycoside poisoning.
Review in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Drug repurposing in oncology: a systematic review of anticancer effects of Lanatoside C at the molecular level.BMC cancer · 2025Pooled it
- Drug repositioning: Progress and challenges in drug discovery for various diseases.European journal of medicinal chemistry · 2022Pooled it
- Toxidromes.Nature reviews. Disease primers · 2026Review
- Toxic Plants Potentially Impacting the Health Status of Livestock in St. Kitts-A Surveillance Study.Toxins · 2026Article
- When herbal supplements cause heart problems: Clinical case report and forensic toxicological analysis.Toxicology reports · 2026Article
- Review
- HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction ofHeliyon · 2025Article
- Antidote use for cardiac arrest or hemodynamic instability due to cardiac glycoside poisoning: A narrative review.Resuscitation plus · 2024Review
- Poisoning byAnimals : an open access journal from MDPI · 2024Article
- Toxicity of House Plants to Pet Animals.Toxins · 2023Review
- Persistent Cardioactive Glycosides Intoxication Related to Gastric Phytobezoar of Oleander Leaves.European journal of case reports in internal medicine · 2023Article
- A review of chemical defense in harlequin toads (Bufonidae:Toxicon: X · 2022Review
- Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology.Frontiers in pharmacology · 2022Review
- Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics.Biomolecules · 2021Review
- The Daniel K. Inouye College of Pharmacy Scripts: The Tantalizing Toxins of Tantalus, A Brief Review of Select Natural Poisons of O'ahu.Hawai'i journal of health & social welfare · 2021Review
- Toxicity of herbal medications suggested as treatment for COVID-19: A narrative review.Journal of the American College of Emergency Physicians open · 2021Review
- Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts.Nanomaterials (Basel, Switzerland) · 2021Review
- Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis.International journal of molecular sciences · 2021Review
- InContext: curation of medical context for drug indications.Journal of biomedical semantics · 2021Article
- Outbreak of Oleander (Toxins · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac glycosides are an important cause of poisoning, reflecting their widespread clinical usage and presence in natural sources. Poisoning can manifest as varying degrees of toxicity. Predominant clinical features include gastrointestinal signs, bradycardia and heart block. Death occurs from ventricular fibrillation or tachycardia. A wide range of treatments have been used, the more common including activated charcoal, atropine, β-adrenoceptor agonists, temporary pacing, anti-digoxin Fab and magnesium, and more novel agents include fructose-1,6-diphosphate (clinical trial in progress) and anticalin. However, even in the case of those treatments that have been in use for decades, there is debate regarding their efficacy, the indications and dosage that optimizes outcomes. This contributes to variability in use across the world. Another factor influencing usage is access. Barriers to access include the requirement for transfer to a specialized centre (for example, to receive temporary pacing) or financial resources (for example, anti-digoxin Fab in resource poor countries). Recent data suggest that existing methods for calculating the dose of anti-digoxin Fab in digoxin poisoning overstate the dose required, and that its efficacy may be minimal in patients with chronic digoxin poisoning. Cheaper and effective medicines are required, in particular for the treatment of yellow oleander poisoning which is problematic in resource poor countries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.