ArticleEndocrinology2016
Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.
Open access · bronzeAbstract read
In one paragraph
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- β-Cell Neogenesis From the Pancreatic Ductal Epithelium Revealed Dynamically by Long-term Intravital Imaging.Diabetes · 2025Article
- Contribution of cytokeratin 19-expressing cells towards islet regeneration induced by multipotent stromal cell secreted proteins.Stem cells (Dayton, Ohio) · 2025Article
- Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123.Nature communications · 2025Article
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- EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors.Signal transduction and targeted therapy · 2024Article
- β-Cell Regeneration Is Driven by Pancreatic Plasticity.Advances in anatomy, embryology, and cell biology · 2024Review
- Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes.Frontiers in endocrinology · 2023Review
- Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement.Endocrinology · 2022Article
- MNK2 deficiency potentiates β-cell regeneration via translational regulation.Nature chemical biology · 2022Article
- Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide.International journal of molecular sciences · 2022Article
- Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes.Frontiers in cell and developmental biology · 2022Article
- Local islet remodelling associated with duct lesion-islet complex in adult human pancreas.Diabetologia · 2021Article
- Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation.Nature communications · 2021Article
- Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas.Nature metabolism · 2021Article
- Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass.Frontiers in endocrinology · 2021Review
- Regenerating β cells of the pancreas - potential developments in diabetes treatment.Expert opinion on biological therapy · 2018Review
- Article
- Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.Scientific reports · 2017Article
- CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors.Endocrinology · 2017Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Yousef El-GoharyDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
John WierschDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Sidhartha TulachanDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Xiangwei XiaoDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Ping GuoDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Christopher RymerDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Shane FischbachDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Krishna PrasadanDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Chiyo ShiotaDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Iljana GaffarDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Zewen SongDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Csaba GalambosDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Farzad EsniDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
George K GittesDepartments of Surgery (Y.E.-G., J.W., X.X., P.G., K.P., C.S., I.G., Z.S., F.E., G.K.G.) and Pediatrics (C.R.), Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224; Department of Surgery (Y.E.-G.), Stony Brook University Medical Center, Stony Brook, New York 11794; Department of Surgery (J.W.), University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Section of Gastroenterology/Hepatology (S.T.), Georgia Regents University, Augusta, Georgia 30912; Division of Biology and Medicine (S.F.), Brown University, Providence, Rhode Island 02912; Department of General Surgery (Z.S.), The Third Xiangya Hospital of Central South University, Yuelu, Changsha, Hunan 410013, China; and Department of Pathology and Laboratory Medicine (C.G.), Children's Hospital Colorado, Aurora, Colorado 80045.
Augusta University · USBrown University · USCentral South University · CNChildren's Hospital Colorado · USChildren's Hospital of Pittsburgh · USStony Brook University Hospital · USThe University of Texas Health Science Center at San Antonio · US
Funding
Evaluation of signals mediating beta-cell regenerationR01DK101413 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ESNI, FARZAD · 2015 to 2019
$1.7MSmad Regulation of Pancreatic Islet FormationR01DK083541 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GITTES, GEORGE K. · 2009 to 2012
$1.4MPancreatic Intra-Islet DuctsR01DK098196 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GITTES, GEORGE K. · 2013 to 2014
$667kNIDDK NIH HHS R01 DK083541NIDDK NIH HHS R01 DK098196NIDDK NIH HHS R01 DK101413
Abstract
A key question in diabetes research is whether new β-cells can be derived from endogenous, nonendocrine cells. The potential for pancreatic ductal cells to convert into β-cells is a highly debated issue. To date, it remains unclear what anatomical process would result in duct-derived cells coming to exist within preexisting islets. We used a whole-mount technique to directly visualize the pancreatic ductal network in young wild-type mice, young humans, and wild-type and transgenic mice after partial pancreatectomy. Pancreatic ductal networks, originating from the main ductal tree, were found to reside deep within islets in young mice and humans but not in mature mice or humans. These networks were also not present in normal adult mice after partial pancreatectomy, but TGF-β receptor mutant mice demonstrated formation of these intraislet duct structures after partial pancreatectomy. Genetic and viral lineage tracings were used to determine whether endocrine cells were derived from pancreatic ducts. Lineage tracing confirmed that pancreatic ductal cells can typically convert into new β-cells in normal young developing mice as well as in adult TGF-β signaling mutant mice after partial pancreatectomy. Here the direct visual evidence of ducts growing into islets, along with lineage tracing, not only represents strong evidence for duct cells giving rise to β-cells in the postnatal pancreas but also importantly implicates TGF-β signaling in this process.
Indexed as
Cell TransdifferentiationAdolescentAge FactorsAnimalsCadaverChild, PreschoolFemaleHumansInfantInsulinInsulin-Secreting CellsIslets of LangerhansLuminescent ProteinsMaleMice, Mutant StrainsMice, TransgenicInsulinLuminescent ProteinsMutant ProteinsProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IIRed Fluorescent Protein
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