ArticleScience advances2015
Prefrontal inputs to the amygdala instruct fear extinction memory formation.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
What it found
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The trial behind it
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Who cites it
152 citing papers in PubMed.
- Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial.Translational psychiatry · 2026Trial
- Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Ayahuasca Impairs Fear Memory Reconsolidation and Promotes Rapid Structural Plasticity in the Hippocampus and Prelimbic Cortex.Molecular neurobiology · 2026Article
- Daily rhythms in fear extinction memory reflect structural and functional changes in a prefrontal-amygdala circuit.Brain structure & function · 2026Article
- Conative inference as a mechanism of allostatic resilience: wanting to be and being to want.Cognitive, affective & behavioral neuroscience · 2026Review
- Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus.Experimental & molecular medicine · 2026Article
- A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory.Journal of advanced research · 2026Article
- Sex-dependent neurobiological and metabolic dysfunction in an aged rat model of post-traumatic stress disorder.Communications biology · 2026Article
- Development and validation of the lifetime sense of safety scale in Kenyan adults.Communications medicine · 2026Article
- Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.Psychopharmacology · 2026Article
- Sex-specific frontal cortical circuit mechanisms mediating fear extinction.bioRxiv : the preprint server for biology · 2026Article
- Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation.Cell biology and toxicology · 2026Article
- Review
- Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation.Nature reviews. Neuroscience · 2025Review
- Article
- PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation.Molecular brain · 2025Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- Article
- Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood.Developmental cognitive neuroscience · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders. However, the neural circuits mediating the extinction of traumatic fear memories remain incompletely understood. We show that selective, in vivo stimulation of the ventromedial prefrontal cortex (vmPFC)-amygdala pathway facilitated extinction memory formation, but not retrieval. Conversely, silencing the vmPFC-amygdala pathway impaired extinction formation and reduced extinction-induced amygdala activity. Our data demonstrate a critical instructional role for the vmPFC-amygdala circuit in the formation of extinction memories. These findings advance our understanding of the neural basis of persistent fear, with implications for posttraumatic stress disorder and other anxiety disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.