Evidence map›Paper›PMID 26504858›Full record

ArticleJournal of immunology research2015

Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt.

Ana Filipa Mourão, Maria José Santos, Sílvia Mendonça, Filipa Oliveira-Ramos, Manuel Salgado, Paula Estanqueiro, José Melo-Gomes, Fernando Martins, Ana Lopes, Bruno Filipe Bettencourt and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ana Filipa MourãoRheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal ; Rheumatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, 1349-019 Lisbon, Portugal ; CEDOC, Faculdade de Ciências Medicas da Universidade Nova de Lisboa, 1150-190 Lisbon, Portugal.
Maria José SantosRheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal ; Rheumatology Department, Hospital Garcia de Orta, 2801-951 Almada, Portugal.
Sílvia MendonçaPortuguese Society of Rheumatology, 1800-033 Lisbon, Portugal.
Filipa Oliveira-RamosRheumatology Department, Lisbon Academic Medical Center, 1649-028 Lisbon, Portugal.
Manuel SalgadoPediatrics Department, Centro Universitário Hospitalar de Coimbra, 3041-801 Coimbra, Portugal.
Paula EstanqueiroPediatrics Department, Centro Universitário Hospitalar de Coimbra, 3041-801 Coimbra, Portugal.
José Melo-GomesPortuguese Society of Rheumatology, 1800-033 Lisbon, Portugal ; Instituto Português de Reumatologia, 1601-901 Lisbon, Portugal.
Fernando MartinsPortuguese Society of Rheumatology, 1800-033 Lisbon, Portugal.
Ana LopesRheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal.
Bruno Filipe BettencourtInstitute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, Portugal ; Hospital de Santo Espírito da Ilha Terceira, SEEBMO, Angra do Heroísmo, 9700-049 Açores, Portugal ; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4150-180 Porto, Portugal.
Jácome Bruges-ArmasInstitute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, Portugal ; Hospital de Santo Espírito da Ilha Terceira, SEEBMO, Angra do Heroísmo, 9700-049 Açores, Portugal ; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4150-180 Porto, Portugal.
José CostaRheumatology Department, Hospital Conde de Bertiandos, ULSAM, 4990-041 Ponte de Lima, Portugal.
Carolina FurtadoRheumatology Department, Hospital do Divino Espírito Santo, São Miguel, 9500-370 Açores, Portugal.
Ricardo FigueiraRheumatology Department, Hospital Dr. Nélio Mendonça, Funchal, 9004-514 Madeira, Portugal.
Iva BritoRheumatology Department, Hospital de São João, 4200-319 Porto, Portugal ; Faculdade de Medicina da Universidade do Porto, 4200-450 Porto, Portugal.
Jaime BrancoRheumatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, 1349-019 Lisbon, Portugal ; CEDOC, Faculdade de Ciências Medicas da Universidade Nova de Lisboa, 1150-190 Lisbon, Portugal.
João Eurico FonsecaRheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal ; Rheumatology Department, Lisbon Academic Medical Center, 1649-028 Lisbon, Portugal.
Helena CanhãoRheumatology Research Unit, Instituto de Medicina Molecular, 1649-028 Lisbon, Portugal ; Rheumatology Department, Lisbon Academic Medical Center, 1649-028 Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA).

methodsOur study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA. We collected prospectively patient and disease characteristics and a blood sample for DNA analysis. Poor prognosis was defined as CHAQ/HAQ >0.75 at the last visit and/or the treatment with biological therapy. A selected panel of single nucleotide polymorphisms (SNPs) associated with susceptibility was studied to verify if there was association with poor prognosis.

resultsOf the 812 patients with JIA registered in Reuma.pt, 267 had a blood sample and registered information used to define "poor prognosis." In univariate analysis, we found significant associations with poor prognosis for allele A of TNFA1P3/20 rs6920220, allele G of TRAF1/C5 rs3761847, and allele G of PTPN2 rs7234029. In multivariate models, the associations with TRAF1/C5 (1.96 [1.17-3.3]) remained significant at the 5% level, while TNFA1P3/20 and PTPN2 were no longer significant. Nevertheless, none of associations found was significant after the Bonferroni correction was applied.

conclusionOur study does not confirm the association between a panel of selected SNP and poor prognosis in Portuguese patients with JIA.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAge of OnsetAllelesArthritis, JuvenileChildChild, PreschoolFemaleHumansMaleOdds RatioPopulation SurveillancePortugalPrognosisRegistries

Identifiers

PMID26504858
PMCPMC4609464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.