Evidence map›Paper›PMID 26504821›Full record

ReviewBioMed research international2015

Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review.

N A P van Gestel, J Geurts, D J W Hulsen, B van Rietbergen, S Hofmann, J J Arts

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05049915 (Evaluation of the Clinical Effectiveness of Bioactive Glass), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05049915 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Evaluation of the Clinical Effectiveness of Bioactive Glass (S53P4) in the Treatment of Non-unions of the Tibia and Femur: a Randomized Controlled Non-inferiority Trial

TypeinterventionalSponsorSebastian FindeisenRan2018 to 2022Enrolled50ConditionsPseudoarthrosis of BoneArmsbioglass (S53P4), RIA and TCP
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.

  1. Pooled it
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  9. Long-term follow-up of patients with large segmental bone defects treated with 3D-printed polycaprolactone/tricalcium phosphate scaffolds.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

N A P van GestelOrthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
J GeurtsDepartment of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
D J W HulsenDepartment of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
B van RietbergenOrthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
S HofmannOrthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Institute for Biomechanics, Swiss Federal Institute of Technology Zürich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
J J ArtsOrthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Department of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
Eindhoven University of Technology · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, grafting of benign bone tumour defects, instrumental spondylodesis, and the treatment of osteomyelitis. Given the reported results that are based on examinations, such as clinical examinations by the surgeons, radiographs, CT, and MRI images, S53P4 bioactive glass may be beneficial in the various reported applications. Especially in craniofacial reconstructions like mastoid obliteration and orbital floor reconstructions, in grafting bone tumour defects, and in the treatment of osteomyelitis very promising results are obtained. Randomized clinical trials need to be performed in order to determine whether bioactive glass would be able to replace the current golden standard of autologous bone usage or with the use of antibiotic containing PMMA beads (in the case of osteomyelitis).

Indexed as

Bone SubstitutesGlassFracture HealingHumansOsteomyelitisbioactive glass S53P4Bone Substitutes

Identifiers

PMID26504821
PMCPMC4609389
OpenAlexW1913595205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.