Evidence map›Paper›PMID 26504785›Full record

ReviewBioMed research international2015

MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis.

Anjie Min, Chao Zhu, Shuping Peng, Saroj Rajthala, Daniela Elena Costea, Dipak Sapkota

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  11. miR-198 targetsFrontiers in oncology · 2024
    Article
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  14. Review
  15. Article
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  17. Disease markers · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Anjie MinDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China.
Chao ZhuDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China ; School of Stomatology, Central South University, Changsha, China.
Shuping PengCancer Research Institute, Central South University, Changsha, China.
Saroj RajthalaThe Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway.
Daniela Elena CosteaThe Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
Dipak SapkotaThe Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway.
Central South University · CNUniversity of Bergen · NOHaukeland University Hospital · NOXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth most common type of human cancer worldwide. The number of new OSCC cases is increasing worldwide, especially in the low-income countries, and the prognosis remains poor in spite of recent advances in the diagnostic and therapeutic modalities. MicroRNAs (miRNAs), 18-25 nucleotides long noncoding RNA molecules, have recently gained significant attention as potential regulators and biomarkers for carcinogenesis. Recent data show that several miRNAs are deregulated in OSCC, and they have either a tumor suppressive or an oncogenic role in oral carcinogenesis. This review summarizes current knowledge on the role of miRNAs as tumor promotors or tumor suppressors in OSCC development and discusses their potential value as diagnostic and prognostic markers in OSCC.

Indexed as

AnimalsBiomarkers, TumorCarcinoma, Squamous CellEvidence-Based MedicineHead and Neck NeoplasmsHumansMicroRNAsMouth NeoplasmsReproducibility of ResultsSensitivity and SpecificitySquamous Cell Carcinoma of Head and NeckBiomarkers, TumorMicroRNAs

Identifiers

PMID26504785
PMCPMC4609509
OpenAlexW1826871104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.