Evidence map›Paper›PMID 26504665›Full record

ArticleBiomedical optics express2015

Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature.

Hamid Pahlevaninezhad, Anthony M D Lee, Alexander Ritchie, Tawimas Shaipanich, Wei Zhang, Diana N Ionescu, Geoffrey Hohert, Calum MacAulay, Stephen Lam, Pierre Lane

Registry-linked trialAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03285841 (Co-registered Multimodal Optical Imaging for the Early Detection and Management of Cancers of the Vulva and Cervix), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03285841 terminatednot on this mapstarted 2019, after this paper: background citation

Co-registered Multimodal Optical Imaging for the Early Detection and Management of Cancers of the Vulva and Cervix

TypeobservationalSponsorBritish Columbia Cancer AgencyRan2019 to 2020Enrolled20ConditionsCervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar CancerArmsOCT-AFI
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Biomedical optics express · 2019
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamid PahlevaninezhadDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Anthony M D LeeDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Alexander RitchieDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Tawimas ShaipanichDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Wei ZhangDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Diana N IonescuDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Geoffrey HohertDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Calum MacAulayDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Stephen LamDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Pierre LaneDepartment of Integrative Oncology, British Columbia Cancer Research Center, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual presentation for the rapid identification of suspicious airway sites, while co-registered OCT provides detailed structural information to assess the airway morphology. We demonstrate the ability of AFI to visualize vascular networks in vivo and validate this finding using Doppler and structural OCT. Given the advantages of higher resolution, smaller probe size, and ability to visualize vasculature, DOCT-AFI has the potential to increase diagnostic accuracy and minimize bleeding to guide biopsy of pulmonary nodules compared to radial endobronchial ultrasound, the current standard of care.

Indexed as

(170.0110) Imaging systems(170.0170) Medical optics and biotechnology(170.2520) Fluorescence microscopy(170.4500) Optical coherence tomography

Identifiers

PMID26504665
PMCPMC4605074

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.