Evidence map›Paper›PMID 26504630›Full record

ArticleBiomedical optics express2015

Precancerous esophageal epithelia are associated with significantly increased scattering coefficients.

Jing-Wei Su, Yang-Hsien Lin, Chun-Ping Chiang, Jang-Ming Lee, Chao-Mao Hsieh, Min-Shu Hsieh, Pei-Wen Yang, Chen-Ping Wang, Ping-Huei Tseng, Yi-Chia Lee and 1 more

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Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing-Wei SuInstitute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan.
Yang-Hsien LinInstitute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan.
Chun-Ping ChiangDepartment of Dentistry, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Jang-Ming LeeDepartment of Surgery, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Chao-Mao HsiehInstitute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan.
Min-Shu HsiehDepartment of Pathology, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Pei-Wen YangDepartment of Surgery, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Chen-Ping WangDepartment of Otolaryngology, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Ping-Huei TsengDepartment of Internal Medicine, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Yi-Chia LeeDepartment of Internal Medicine, National Taiwan University Hospital, Taiwan ; National Taiwan University College of Medicine, Taiwan.
Kung-Bin SungInstitute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan ; Department of Electrical Engineering, National Taiwan University, Taiwan ; Molecular Imaging Center, National Taiwan University, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The progression of epithelial precancers into cancer is accompanied by changes of tissue and cellular structures in the epithelium. Correlations between the structural changes and scattering coefficients of esophageal epithelia were investigated using quantitative phase images and the scattering-phase theorem. An ex vivo study of 14 patients demonstrated that the average scattering coefficient of precancerous epithelia was 37.8% higher than that of normal epithelia from the same patient. The scattering coefficients were highly correlated with morphological features including the cell density and the nuclear-to-cytoplasmic ratio. A high interpatient variability in scattering coefficients was observed and suggests identifying precancerous lesions based on the relative change in scattering coefficients.

Indexed as

(170.0180) Microscopy(170.4580) Optical diagnostics for medicine(170.6935) Tissue characterization(290.7050) Turbid media

Identifiers

PMID26504630
PMCPMC4605039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.