Evidence map›Paper›PMID 26504628›Full record

ArticleBiomedical optics express2015

Review of fluorescence guided surgery visualization and overlay techniques.

Jonathan T Elliott, Alisha V Dsouza, Scott C Davis, Jonathan D Olson, Keith D Paulsen, David W Roberts, Brian W Pogue

Registry-linked trialAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02691923 (Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02691923 phase2active not recruitingnot on this mapstarted 2016, after this paper: background citation

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology

TypeinterventionalSponsorDavid W. RobertsRan2016 to 2028Enrolled30ConditionsBrain CancerArmsFluorescein, Fluorescein + ALA
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan T ElliottThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
Alisha V DsouzaThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
Scott C DavisThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
Jonathan D OlsonNeurosurgery Section, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03766, USA.
Keith D PaulsenThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
David W RobertsNeurosurgery Section, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03766, USA ; Department of Surgery, Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH 03755, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA ; Department of Surgery, Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH 03755, USA.

Funding

Molecular Fluorescence-Guided Surgery PlatformR01CA167413 · NCI · DARTMOUTH COLLEGE · PI PAULSEN, KEITH D., SAMKOE, KIMBERLEY · 2013 to 2025
$5.7M
Fluorescence Imaging to Optimize Cancer TherapyR01CA109558 · NCI · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2005 to 2015
$2.8M
MRI fluorescence tomography for quantifying tumor receptor concentration in vivoR01CA184354 · NCI · DARTMOUTH COLLEGE · PI DAVIS, SCOTT C · 2014 to 2018
$2.6M
NCI NIH HHS R01 CA109558NCI NIH HHS R01 CA167413NCI NIH HHS R01 CA184354
6 · The paper itself

Abstract

In fluorescence guided surgery, data visualization represents a critical step between signal capture and display needed for clinical decisions informed by that signal. The diversity of methods for displaying surgical images are reviewed, and a particular focus is placed on electronically detected and visualized signals, as required for near-infrared or low concentration tracers. Factors driving the choices such as human perception, the need for rapid decision making in a surgical environment, and biases induced by display choices are outlined. Five practical suggestions are outlined for optimal display orientation, color map, transparency/alpha function, dynamic range compression, and color perception check.

Indexed as

(170.1610) Clinical applications(170.3880) Medical and biological imaging(170.4730) Optical pathology(260.2510) Fluorescence(330.1730) Colorimetry(330.5020) Perception psychology

Identifiers

PMID26504628
PMCPMC4605037

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.