ArticleBiomedical optics express2015
Handheld imaging photonic crystal biosensor for multiplexed, label-free protein detection.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors.Optica · 2025Article
- Article
- Intensity-Based Camera Setup for Refractometric and Biomolecular Sensing with a Photonic Crystal Microfluidic Chip.Biosensors · 2023Article
- Spatially Resolved Protein Binding Kinetics Analysis in Microfluidic Photonic Crystal Sensors.Sensors (Basel, Switzerland) · 2023Article
- Label-free multiplex sensing from buffer and immunoglobulin G sensing from whole blood with photonic crystal slabs using angle-tuning of an optical interference filter.Biomedical optics express · 2023Article
- Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders.Sensors (Basel, Switzerland) · 2022Review
- Monolithic Integrated OLED-OPD Unit for Point-of-Need Nitrite Sensing.Sensors (Basel, Switzerland) · 2022Article
- Article
- Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting.Molecules (Basel, Switzerland) · 2021Article
- A compact photonic resonator absorption microscope for point of care digital resolution nucleic acid molecular diagnostics.Biomedical optics express · 2021Article
- Multiplex optical biosensors based on multi-pinhole interferometry.Biomedical optics express · 2021Article
- Near cut-off wavelength operation of resonant waveguide grating biosensors.Scientific reports · 2021Article
- Review
- Guided Mode Resonance Sensors with Optimized Figure of Merit.Nanomaterials (Basel, Switzerland) · 2019Article
- A Diagnostic Device for In-Situ Detection of Swine Viral Diseases: The SWINOSTICS Project.Sensors (Basel, Switzerland) · 2019Article
- Cascaded-Microrings Biosensors Fabricated on a Polymer Platform.Sensors (Basel, Switzerland) · 2019Article
- Investigation of Grating-Assisted Trimodal Interferometer Biosensors Based on a Polymer Platform.Sensors (Basel, Switzerland) · 2018Article
- Dielectric barrier discharge plasma treatment of modified SU-8 for biosensing applications.Biomedical optics express · 2018Article
- Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager.Light, science & applications · 2018Article
- Dual-Mode Electro-Optical Techniques for Biosensing Applications: A Review.Sensors (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a handheld biosensor system for the label-free and specific multiplexed detection of several biomarkers employing a spectrometer-free imaging measurement system. A photonic crystal surface functionalized with multiple specific ligands forms the optical transducer. The photonic crystal slab is fabricated on a glass substrate by replicating a periodic grating master stamp with a period of 370 nm into a photoresist via nanoimprint lithography and deposition of a 70-nm titanium dioxide layer. Capture molecules are coupled covalently and drop-wise to the photonic crystal surface. With a simple camera and imaging optics the surface-normal transmission is detected. In the transmission spectrum guided-mode resonances are observed that shift due to protein binding. This shift is observed as an intensity change in the green color channel of the camera. Non-functionalized image sections are used for continuous elimination of background drift. In a first experiment we demonstrate the specific and time-resolved detection of 90.0 nm CD40 ligand antibody, 90.0 nM EGF antibody, and 500 nM streptavidin in parallel on one sensor chip. In a second experiment, aptamers with two different spacer lengths are used as receptor. The binding kinetics with association and dissociation of 250 nM thrombin and regeneration of the sensor surface with acidic tris-HCl-buffer (pH 5.0) is presented for two measurement cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.