Evidence map›Paper›PMID 26504623›Full record

ArticleBiomedical optics express2015

In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles.

Yu Winston Wang, Soyoung Kang, Altaz Khan, Philip Q Bao, Jonathan T C Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Application and Progress of Raman Spectroscopy in Male Reproductive System.Frontiers in cell and developmental biology · 2021
    Review
  15. Multiplexed Raman Imaging in Tissues and Living Organisms.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  16. Article
  17. Nanoparticles in Gastrooncology.Visceral medicine · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu Winston WangDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA.
Soyoung KangDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA.
Altaz KhanDepartment of Biomedical Engineering, Stony Brook University (SUNY), Stony Brook, NY 11794, USA.
Philip Q BaoDepartment of Surgery, Stony Brook Medicine, Stony Brook, NY 11794, USA.
Jonathan T C LiuDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA.

Funding

Endoscopic molecular imaging of esophageal cancer with multiplexed Raman nanopartR21EB015016 · NIBIB · UNIVERSITY OF WASHINGTON · PI LIU, JONATHAN T.C. · 2013 to 2014
$493k
NIBIB NIH HHS R21 EB015016
6 · The paper itself

Abstract

The biological investigation and detection of esophageal cancers could be facilitated with an endoscopic technology to screen for the molecular changes that precede and accompany the onset of cancer. Surface-enhanced Raman scattering (SERS) nanoparticles (NPs) have the potential to improve cancer detection and investigation through the sensitive and multiplexed detection of cell-surface biomarkers. Here, we demonstrate that the topical application and endoscopic imaging of a multiplexed cocktail of receptor-targeted SERS NPs enables the rapid detection of tumors in an orthotopic rat model of esophageal cancer. Antibody-conjugated SERS NPs were topically applied on the lumenal surface of the rat esophagus to target EGFR and HER2, and a miniature spectral endoscope featuring rotational scanning and axial pull-back was employed to comprehensively image the NPs bound on the lumen of the esophagus. Ratiometric analyses of specific vs. nonspecific binding enabled the visualization of tumor locations and the quantification of biomarker expression in agreement with immunohistochemistry and flow cytometry validation data.

Indexed as

(110.2350) Fiber optics imaging(160.4236) Nanomaterials(170.0170) Medical optics and biotechnology(170.2150) Endoscopic imaging(170.2680) Gastrointestinal(170.5660) Raman spectroscopy

Identifiers

PMID26504623
PMCPMC4605032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.