Evidence map›Paper›PMID 26504622›Full record

ArticleBiomedical optics express2015

Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy.

Ji Yi, Siyu Chen, Xiao Shu, Amani A Fawzi, Hao F Zhang

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 87 citations in OpenAlex.

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  10. Frontiers in ophthalmology · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ji YiDepartment of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL, 60208 USA ; These authors contributed equally to this work.
Siyu ChenDepartment of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL, 60208 USA ; These authors contributed equally to this work.
Xiao ShuDepartment of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL, 60208 USA ; These authors contributed equally to this work.
Amani A FawziDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Chicago, IL 60611 USA.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL, 60208 USA ; Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Chicago, IL 60611 USA.
Northwestern University · US

Funding

Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
NEI NIH HHS R01 EY019951NEI NIH HHS R24 EY022883
6 · The paper itself

Abstract

We achieved human retinal imaging using visible-light optical coherence tomography (vis-OCT) guided by an integrated scanning laser ophthalmoscopy (SLO). We adapted a spectral domain OCT configuration and used a supercontinuum laser as the illumating source. The center wavelength was 564 nm and the bandwidth was 115 nm, which provided a 0.97 µm axial resolution measured in air. We characterized the sensitivity to be 86 dB with 226 µW incidence power on the pupil. We also integrated an SLO that shared the same optical path of the vis-OCT sample arm for alignment purposes. We demonstrated the retinal imaging from both systems centered at the fovea and optic nerve head with 20° × 20° and 10° × 10° field of view. We observed similar anatomical structures in vis-OCT and NIR-OCT. The contrast appeared different from vis-OCT to NIR-OCT, including slightly weaker signal from intra-retinal layers, and increased visibility and contrast of anatomical layers in the outer retina.

Indexed as

(110.4190) Multiple imaging(170.0110) Imaging systems(170.4470) Ophthalmology(170.4500) Optical coherence tomography

Identifiers

PMID26504622
PMCPMC4605031
OpenAlexW1884342291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.