ArticleBMJ open diabetes research & care2015
Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes.
Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis.Medical microbiology and immunology · 2019Pooled it
- Immunogenicity, safety, and effectiveness of seasonal influenza vaccination in patients with diabetes mellitus: A systematic review.Human vaccines & immunotherapeutics · 2018Pooled it
- Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults.Vaccine · 2025Trial
- Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.Experimental gerontology · 2018Trial
- [Smoking and nicotine use, heated tobacco products, psychological and socioeconomic aspects of dependence, alcohol, infections, vaccination and diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Article
- Insulin deficiency inhibits vaccine-mediated antibody and germinal center B-cell formation in mice.bioRxiv : the preprint server for biology · 2025Article
- Role of the Virome in Vaccine-Induced Immunization.Vaccines · 2025Review
- Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations.Cell reports. Medicine · 2025Article
- Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes.COVID · 2025Article
- Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection.EBioMedicine · 2024Article
- How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024Review
- Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation.Frontiers in aging · 2024Article
- Review
- Immune Response to CoronaVac and Its Safety in Patients with Type 2 Diabetes Compared with Healthcare Workers.Vaccines · 2023Article
- Influenza vaccination in patients affected by diabetes.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults.NPJ vaccines · 2022Article
- Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Role of Immunosenescence in Cerebral Small Vessel Disease: A Review.International journal of molecular sciences · 2022Review
- Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults.Influenza and other respiratory viruses · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveType 2 diabetes mellitus (T2DM) is one of the most prevalent chronic inflammatory diseases of the elderly. Its development is related to the alteration of the immune system with aging characterized by immunosenescence and inflamm-aging. In turn, T2DM also alters the immune response. As a consequence, older people with T2DM are more susceptible to influenza and to its complications as compared with healthy controls. Vaccination against influenza has shown poor efficacy in the older population and even less efficacy in patients with diabetes. We studied here the antibody response to vaccination in healthy and diabetic elderly participants. RESEARCH DESIGN AND
methodsIn 2 groups of elderly participants (healthy N=119 and T2DM N=102), we measured the immunogenicity of influenza vaccine by hemagglutination inhibition assays. We assessed several blood and functional parameters as potential predictors of the vaccine efficacy.
resultsWe found no difference between antibody responses in diabetic elderly compared with healthy elderly. Among the biological and functional determinants, the cytomegalovirus (CMV) serostatus played a more prominent role in determining the magnitude of response. We concluded that in addition to age and diabetic status, immunological history such as CMV status should be taken into account. None of the other biological or functional parameters studied could be reliably linked to the vaccine antibody response in older adults who are not frail including those with well-controlled diabetes.
conclusionsOur data strongly suggest that influenza vaccine should be administered to elderly patients with T2DM; however, the immune determinants of the antibody response to influenza vaccination should be further investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.