ArticleInfectious agents and cancer2015
Inconclusive role of human papillomavirus infection in breast cancer.
Article in Infectious agents and cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- HPV-Associated Breast Cancer: Myth or Fact?Pathogens (Basel, Switzerland) · 2022Review
- Detection of High-Risk Human Papillomavirus DNA in Invasive Ductal Carcinoma Specimens.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease.Current issues in molecular biology · 2022Article
- Low frequency of HPV positivity in breast tumors among patients from south-central Poland.Infectious agents and cancer · 2021Article
- The scope of viral causation of human cancers: interpreting virus density from an evolutionary perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Low Prevalence of Human Papilloma Virus in Patients with Breast Cancer, Kerman; IranAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes.World journal of clinical oncology · 2018Article
- HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer.Oncology letters · 2018Article
- No Significant Association between Human Papillomavirus and Breast Cancer, Sanandaj, IranAsian Pacific journal of cancer prevention : APJCP · 2016Article
- Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer.British journal of cancer · 2016Article
- Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies.Infectious agents and cancer · 2016Article
- Human Papilloma Viruses and Breast Cancer - Assessment of Causality.Frontiers in oncology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies have examined the association between human papillomavirus (HPV) and breast cancer, but the findings are inconclusive. This study aimed to detect the prevalence of HPV in breast cancer tissue in patients from northeastern China and define the association between HPV and breast cancer using meta-analysis.
methodsPolymerase chain reaction (PCR) was used to test cutaneous or mucosal HPV DNA sequence in 77 breast cancer samples and 77 corresponding adjacent normal tissues. The prevalence of HPV in breast cancer was estimated by pooling data from 38 studies. A meta-analysis of 16 case-control studies was conducted to investigate the association between HPV and breast cancer.
resultsWe did not find HPV DNA sequence in any of the 154 tissue specimens we tested. However, our meta-analysis revealed a HPV prevalence of 30.30 % (95 % confidence interval [CI] = 22.30-38.40 %) among breast cancer cases; most of these involved high-risk HPV types (35.50 %, 95 % CI = 25.00-46.10 %). HPV prevalence in breast cancer varied by geographic region, publication period, and PCR detection method. An increased risk of breast cancer was observed in association with exposure to HPV (odds ratio [OR] = 3.24, 95 % CI = 1.59-6.57), which was influenced by geographic region, HPV DNA source, PCR primer used, and publication period.
conclusionsHPV, especially high-risk HPV types, may be associated with an increased risk of breast cancer, and this association varies dramatically among geographic regions.
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