Evidence map›Paper›PMID 26504359›Full record

ReviewMediators of inflammation2015

Cancer Cachexia and MicroRNAs.

Rodolfo Gonzalez Camargo, Henrique Quintas Teixeira Ribeiro, Murilo Vieira Geraldo, Emídio Matos-Neto, Rodrigo Xavier Neves, Luiz Carlos Carnevali, Felipe Fedrizzi Donatto, Paulo S M Alcântara, José P Ottoch, Marília Seelaender

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Review
  6. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Review
  15. A Pound of Flesh: What Cachexia Is and What It Is Not.Diagnostics (Basel, Switzerland) · 2021
    Review
  16. Sex Differences in Cancer Cachexia.Current osteoporosis reports · 2020
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Rodolfo Gonzalez CamargoCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil ; NAPmiR-miRNA Research Group, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Henrique Quintas Teixeira RibeiroCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Murilo Vieira GeraldoNAPmiR-miRNA Research Group, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Emídio Matos-NetoCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Rodrigo Xavier NevesCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Luiz Carlos CarnevaliCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Felipe Fedrizzi DonattoCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Paulo S M AlcântaraDepartment of Clinical Surgery, University of São Paulo, Avenida Professor Lineu Prestes 2565, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
José P OttochDepartment of Clinical Surgery, University of São Paulo, Avenida Professor Lineu Prestes 2565, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Marília SeelaenderCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil ; NAPmiR-miRNA Research Group, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Universidade de São Paulo · BRInstitute of Biomedical Science · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment.

Indexed as

Adipose TissueAnimalsBody WeightCachexiaCytokinesHumansInflammationMicroRNAsMuscle, SkeletalNeoplasmsSignal TransductionWeight LossCytokinesMicroRNAs

Identifiers

PMID26504359
PMCPMC4609493
OpenAlexW1859804035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.