ArticleProceedings of the National Academy of Sciences of the United States of America2015
Behavioral assessment of sensitivity to intracortical microstimulation of primate somatosensory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.Neurology · 2022Trial
- Linking spatially distributed neuronal activation overlap to the limits of perceptual discrimination in rodent primary somatosensory cortex.Frontiers in computational neuroscience · 2026Article
- Improved electrode stimulation stability of Utah arraysBioelectronic medicine · 2025Article
- Early intervention with electrical stimulation reduces neural damage after stroke in non-human primates.Nature communications · 2025Article
- Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.Nature biomedical engineering · 2025Article
- Investigating the spatial limits of somatotopic and depth-dependent sensory discrimination stimuli in rats via intracortical microstimulation.Frontiers in neuroscience · 2025Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation.Nature biomedical engineering · 2024Article
- Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice.Journal of neural engineering · 2024Article
- Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024Review
- Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation.iScience · 2023Article
- Biomimetic multi-channel microstimulation of somatosensory cortex conveys high resolution force feedback for bionic hands.bioRxiv : the preprint server for biology · 2023Article
- Neuronal Spiking Responses to Direct Electrical Microstimulation in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Restoration of sensory information via bionic hands.Nature biomedical engineering · 2023Review
- An implantable wireless tactile sensing system.Research square · 2023Article
- Editorial: Safety and efficacy evaluation of electrical stimulation devices for neural modulation.Frontiers in neuroscience · 2023Article
- An implantable, wireless, battery-free system for tactile pressure sensing.Microsystems & nanoengineering · 2023Article
- A Review: Research Progress of Neural Probes for Brain Research and Brain-Computer Interface.Biosensors · 2022Review
- Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array.Journal of neural engineering · 2022Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracortical microstimulation (ICMS) is a powerful tool to investigate the functional role of neural circuits and may provide a means to restore sensation for patients for whom peripheral stimulation is not an option. In a series of psychophysical experiments with nonhuman primates, we investigate how stimulation parameters affect behavioral sensitivity to ICMS. Specifically, we deliver ICMS to primary somatosensory cortex through chronically implanted electrode arrays across a wide range of stimulation regimes. First, we investigate how the detectability of ICMS depends on stimulation parameters, including pulse width, frequency, amplitude, and pulse train duration. Then, we characterize the degree to which ICMS pulse trains that differ in amplitude lead to discriminable percepts across the range of perceptible and safe amplitudes. We also investigate how discriminability of pulse amplitude is modulated by other stimulation parameters-namely, frequency and duration. Perceptual judgments obtained across these various conditions will inform the design of stimulation regimes for neuroscience and neuroengineering applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.