SynthesisJournal of the American Heart Association2015
Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2015Pooled it
- The incidence and associated factors of pulmonary embolism after cardiac surgery: A retrospective nationwide inpatient sample database study.American heart journal plus : cardiology research and practice · 2026Article
- [Analysis of Clinical Characteristics and Diagnostic Indicators in Patients With Heparin-induced Thrombocytopenia After Cardiac Surgery].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Review
- A Reproducible Post-Valve-Replacement EHR Cohort for Comparative AI Studies.Diagnostics (Basel, Switzerland) · 2026Article
- Incidence of Venous Thromboembolism After Surgery for Acute Stanford Type A Aortic Dissection.Cureus · 2026Article
- Characterizing Acute Pulmonary Embolism After Off-Pump Coronary Artery Bypass Surgery Using a Predictive XGBoost Model.Journal of multidisciplinary healthcare · 2026Article
- Article
- Venous Thromboembolism After Coronary Artery Bypass Increases Health Care Costs: A Propensity Score-Matched Analysis.The Annals of thoracic surgery · 2025Article
- Impact of Sarcopenia and Nutritional Status on Survival of Patients with Aortic Dissection: A Scoping Review.Nutrients · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Inadequate Anti-Factor Xa Levels With Daily 40-mg Enoxaparin After Cardiac Surgery.Annals of thoracic surgery short reports · 2024Article
- Heparin-induced thrombocytopenia after cardiac surgery. A single-center, retrospective cohort study.Research and practice in thrombosis and haemostasis · 2024Article
- A comprehensive deep venous thrombosis prophylaxis regimen in isolated coronary artery bypass grafting.JTCVS open · 2024Article
- Atypical Presentation of a Right Atrial Myxoma.Cureus · 2023Article
- Practice Patterns of Antithrombotic Therapy during the Early Postoperative Course of Cardiac Surgery.Journal of clinical medicine · 2023Article
- Indian Society of Critical Care Medicine Consensus Statement for Prevention of Venous Thromboembolism in the Critical Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis.European cardiology · 2022Review
- A fixed dose approach to thrombosis chemoprophylaxis may be inadequate in heavier critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without complications after cardiac surgery. METHODS AND
resultsTwo reviewers independently searched and assessed the quality and outcomes of randomized, controlled trials (RCTs) and observational studies on VTE after cardiac surgery in the MEDLINE, EMBASE, and Cochrane controlled trial register (1966 to December 2014). Sixty-eight studies provided data on VTE outcomes or complications related to thromboprophylaxis after cardiac surgery. The majority of the studies were observational studies (n=49), 16 studies were RCTs, and 3 were meta-analyses. VTE prophylaxis was associated with a reduced risk of PE (relative risk [RR], 0.45; 95% confidence interval [CI], 0.28-0.72; P=0.0008) or symptomatic VTE (RR, 0.44; 95% CI, 0.28-0.71; P=0.0006) compared to the control without significant heterogeneity. Median incidence (interquartile range) of symptomatic DVT, PE, and fatal PE were 3.2% (0.6-8.1), 0.6% (0.3-2.9), and 0.3% (0.08-1.7), respectively. Previous history of VTE, obesity, left or right ventricular failure, and prolonged bed rest, mechanical ventilation, or use of a central venous catheter were common risk factors for VTE. Bleeding or cardiac tamponade requiring reoperation owing to pharmacological VTE prophylaxis alone, without systemic anticoagulation, was not observed.
conclusionsUnless proven otherwise by adequately powered RCTs, initiating pharmacological VTE prophylaxis as soon as possible after cardiac surgery for patients who have no active bleeding is highly recommended.
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