ArticlePediatrics2015
Growth Charts for Children With Down Syndrome in the United States.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- Systematic review and meta-analysis of balance training in children with developmental disorders.PeerJ · 2026Pooled it
- Achieving Protein Requirements Through Oral Feeding in Children with Congenital Heart Disease: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Bone age estimation from chest radiographs using deep neural networks: a proof-of-concept study.Pediatric radiology · 2026Article
- Factors associated with constipation in critically ill children: A retrospective study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Understanding Severe Sleep-Disordered Breathing in Down Syndrome: Insights from a Clinical-Polysomnographic Cohort.Journal of clinical medicine · 2026Article
- Disease-specific growth charts capture characteristic growth patterns in children with PMM2 - CDG.Molecular genetics and metabolism · 2026Article
- TRISOMY 21: development of syndrome-specific growth charts from a wide Italian cohort and validation of BMI as a predictor of increased risk of metabolic derangement.Journal of endocrinological investigation · 2026Article
- Commentary on the LMSz method: a novel approach to gene-specific growth charts for rare neurodevelopmental disorders.European journal of human genetics : EJHG · 2026Article
- Severity of Congenital Heart Defects Affects Long-Term Somatic Development.Pediatric cardiology · 2026Article
- Article
- The Science of Growth Monitoring: Beyond the Basics.Children (Basel, Switzerland) · 2026Review
- Prevalence of Functional Constipation in Children with Down Syndrome: A Study Conducted at a General Pediatrics Service.Biomedicines · 2026Article
- Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified byScientific reports · 2025Article
- Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function.Journal of clinical immunology · 2025Article
- Cardiopulmonary and Immune Alterations in the Ts65Dn Mouse Model of Down Syndrome and Modulation by Epigallocatechin-3-Gallate-Enriched Green Tea Extract.Pharmaceutics · 2025Article
- Nutrition for Children with Down Syndrome-Current Knowledge, Challenges, and Clinical Recommendations-A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Charting structural brain asymmetry across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Article
- Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening.Frontiers in pediatrics · 2025Article
- Nutritional management of the child with chronic kidney disease and on dialysis.Pediatric nephrology (Berlin, Germany) · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesChildren with Down syndrome (DS) have lower birth weights and grow more slowly than children without DS. Advances in and increased access to medical care have improved the health and well-being of individuals with DS; however, it is unknown whether their growth has also improved. Our objective was to develop new growth charts for children with DS and compare them to older charts from the United States and more contemporary charts from the United Kingdom.
methodsThe Down Syndrome Growing Up Study (DSGS) enrolled a convenience sample of children with DS up to 20 years of age and followed them longitudinally. Growth parameters were measured by research anthropometrists. Sex-specific growth charts were generated for the age ranges birth to 36 months and 2 to 20 years using the LMS method. Weight-for-length and BMI charts were also generated. Comparisons with other curves were presented graphically.
resultsNew DSGS growth charts were developed by using 1520 measurements on 637 participants. DSGS growth charts for children <36 months of age showed marked improvements in weight compared with older US charts. DSGS charts for 2- to 20-year-olds showed that contemporary males are taller than previous charts showed. Generally, the DSGS growth charts are similar to the UK charts.
conclusionsThe DSGS growth charts can be used as screening tools to assess growth and nutritional status and to provide indications of how growth of an individual child compares with peers of the same age and sex with DS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.