Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. An AAV-Based Therapy Approach for Neurological Phenotypes of X-Linked Adrenoleukodystrophy.International journal of molecular sciences · 2025
   Review
2. Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin.Science China. Life sciences · 2023
   Article
3. Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy.Nature communications · 2023
   Article
4. Genetic origin of patients having spastic paraplegia with or without other neurologic manifestations.BMC neurology · 2022
   Article
5. The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies.Frontiers in pharmacology · 2022
   Review
6. Endocrine dysfunction in adrenoleukodystrophy.Handbook of clinical neurology · 2021
   Review
7. X-linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2020
   Review
8. Late onset adrenoleukodystrophy: A review related clinical case report.eNeurologicalSci · 2019
   Review
9. Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients.Fluids and barriers of the CNS · 2018
   Article
10. ABCD1 dysfunction alters white matter microvascular perfusion.Brain : a journal of neurology · 2017
    Article
11. Efficient derivation of microglia-like cells from human pluripotent stem cells.Nature medicine · 2016
    Article

Corrections and comments

• Comment on
  Brain endothelial dysfunction in cerebral adrenoleukodystrophy.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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