ArticleThe pharmacogenomics journal2016
Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children.
Article in The pharmacogenomics journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment in Children With Growth Hormone Deficiency.The Journal of clinical endocrinology and metabolism · 2024Trial
- Gene expression signatures predict response to therapy with growth hormone.The pharmacogenomics journal · 2021Trial
- Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency.JCI insight · 2018Trial
- Seasonality of Children's Height and Weight and Their Contribution to Accelerated Summer Weight Gain.Frontiers in physiology · 2022Article
- Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature.Reviews in endocrine & metabolic disorders · 2021Review
- Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents.Journal of circadian rhythms · 2021Article
- Physiological mechanisms underlying children's circannual growth patterns and their contributions to the obesity epidemic in elementary school age children.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Circannual growth in Wisconsin children and adolescents: Identifying optimal periods of obesity prevention.Pediatric obesity · 2020Article
- The in vitro functional analysis of single-nucleotide polymorphisms associated with growth hormone (GH) response in children with GH deficiency.The pharmacogenomics journal · 2019Article
- Day length may make geographical difference in body size and proportions: An ecological analysis of Japanese children and adolescents.PloS one · 2019Article
- Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study.European journal of endocrinology · 2016Article
- Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats.Oxidative medicine and cellular longevity · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene-environment interactions on growth response to recombinant human growth hormone (r-hGH). Growth responses in children are linked to latitude, and we found that a correlate of latitude, summer daylight exposure (SDE), was a key environmental factor related to growth response to r-hGH. In turn growth response was determined by an interaction between both SDE and genes known to affect growth response to r-hGH. In addition, analysis of associated networks of gene expression implicated a role for circadian clock pathways and specifically the developmental transcription factor NANOG. This work provides the first observation of gene-environment interactions in children treated with r-hGH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.