Evidence map›Paper›PMID 26503810›Full record

ArticleThe pharmacogenomics journal2016

NAT2 gene diversity and its evolutionary trajectory in the Americas.

R Bisso-Machado, V Ramallo, V R Paixão-Côrtes, V Acuña-Alonzo, D A Demarchi, J R S Sandoval, A A S Granara, F M Salzano, T Hünemeier, M C Bortolini

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. International journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Genetics and genomics in Peru: Clinical and research perspective.Molecular genetics & genomic medicine · 2018
    Review
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

R Bisso-MachadoLaboratório de Evolução Humana e Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
V RamalloConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Puerto Madryn, Argentina.
V R Paixão-CôrtesLaboratório de Evolução Humana e Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
V Acuña-AlonzoMolecular Genetics Laboratory, Escuela Nacional de Antropología e Historia, Mexico City, Mexico.
D A DemarchiInstituto de Antropología de Córdoba, CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.
J R S SandovalFacultad de Medicina Humana, Universidad de San Martin de Porres, Lima, Peru.
A A S GranaraFacultad de Medicina Humana, Universidad de San Martin de Porres, Lima, Peru.
F M SalzanoLaboratório de Evolução Humana e Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
T HünemeierDepartamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.
M C BortoliniLaboratório de Evolução Humana e Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2*4, the most frequent haplotypes are NAT2*5B (35.95%) in hunter-gatherers and NAT2*7B (20.61%) and NAT2*5B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ~44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal.

Indexed as

Evolution, MolecularGenetic VariationAcetylationAgricultureAmerican Indian or Alaska NativeAmericasAnimalsArylamine N-AcetyltransferaseDietFeeding BehaviorGene FrequencyHaplotypesHumansKineticsPhenotypePredatory BehaviorArylamine N-AcetyltransferaseNAT2 protein, humanXenobiotics

Identifiers

PMID26503810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.