Evidence map›Paper›PMID 26503755›Full record

ArticleCirculation2015

Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs".

Blerina Ahmetaj-Shala, Nicholas S Kirkby, Rebecca Knowles, Malak Al'Yamani, Sara Mazi, Zhen Wang, Arthur T Tucker, Louise S Mackenzie, Paul C J Armstrong, Rolf M Nüsing and 4 more

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Blerina Ahmetaj-ShalaCardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, UK.
Nicholas S KirkbyCardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, UK.
Rebecca KnowlesThe William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.
Malak Al'YamaniCardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, UK, King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.
Sara MaziCardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, UK, King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.
Zhen WangMRC Clinical Sciences, Imperial College London, Nitric Oxide Signalling Group, Hammersmith Hospital, London, UK.
Arthur T TuckerThe William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.
Louise S MackenzieSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
Paul C J ArmstrongThe William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.
Rolf M NüsingInstitute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
James A P TomlinsonMRC Clinical Sciences, Imperial College London, Nitric Oxide Signalling Group, Hammersmith Hospital, London, UK.
Timothy D WarnerThe William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.
James LeiperMRC Clinical Sciences, Imperial College London, Nitric Oxide Signalling Group, Hammersmith Hospital, London, UK.
Jane A MitchellCardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, UK.

Funding

Medical Research Council MC_U120097118
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnti-Inflammatory AgentsArginineCardiovascular DiseasesCyclooxygenase 2Cyclooxygenase 2 InhibitorsFemaleHumansMaleAnti-Inflammatory AgentsArginineCyclooxygenase 2Cyclooxygenase 2 Inhibitors

Identifiers

PMID26503755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.