ArticleScientific reports2015
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblasts.Stem cell research & therapy · 2021Article
- Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties.PloS one · 2021Article
- [Research progress of hepatocyte transplantation treatment for alpha-1 antitrypsin deficiency].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Article
- HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model.Stem cell research & therapy · 2020Article
- Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells.Stem cell research & therapy · 2020Article
- Robust and Reproducible Generation of Induced Neural Stem Cells from Human Somatic Cells by Defined Factors.International journal of stem cells · 2020Article
- Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion.Stem cells international · 2020Review
- Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes.World journal of stem cells · 2019Review
- Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons.International journal of stem cells · 2019Article
- Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells.Stem cells international · 2019Article
- Direct Conversion of Mouse Fibroblasts into Cholangiocyte Progenitor Cells.Stem cell reports · 2018Article
- Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction.Scientific reports · 2017Article
- Simple Maturation of Direct-Converted Hepatocytes Derived from Fibroblasts.Tissue engineering and regenerative medicine · 2017Article
- Reprogramming cell fates by small molecules.Protein & cell · 2017Review
- Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon.Scientific reports · 2017Article
- Role of Hepatic-Specific Transcription Factors and Polycomb Repressive Complex 2 during Induction of Fibroblasts to Hepatic Fate.PloS one · 2016Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to generate integration-free induced hepatocyte-like cells (iHeps) from somatic fibroblasts has the potential to advance their clinical application. Here, we have generated integration-free, functional, and expandable iHeps from mouse somatic fibroblasts. To elicit this direct conversion, we took advantage of an oriP/EBNA1-based episomal system to deliver a set of transcription factors, Gata4, Hnf1a, and Foxa3, to the fibroblasts. The established iHeps exhibit similar morphology, marker expression, and functional properties to primary hepatocytes. Furthermore, integration-free iHeps prolong the survival of fumarylacetoacetate-hydrolase-deficient (Fah(-/-)) mice after cell transplantation. Our study provides a novel concept for generating functional and expandable iHeps using a non-viral, non-integrating, plasmid-based system that could facilitate their pharmaceutical and biomedical application.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.