ReviewNature reviews. Endocrinology2016
The best of both worlds - managing the cancer, saving the bone.
Review in Nature reviews. Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Diagnostic performance ofOncology letters · 2024Article
- Metabolic regulation of skeletal cell fate and function.Nature reviews. Endocrinology · 2024Review
- Biomaterial-assisted tumor therapy: A brief review of hydroxyapatite nanoparticles and its composites used in bone tumors therapy.Frontiers in bioengineering and biotechnology · 2023Review
- Innovative Biomaterials for the Treatment of Bone Cancer.International journal of molecular sciences · 2021Review
- Primary cilia regulate gastric cancer-induced bone loss via cilia/Wnt/β-catenin signaling pathway.Aging · 2021Article
- 3D Immunocompetent Organ-on-a-Chip Models.Small methods · 2020Article
- Establishment of a serological molecular model for the early diagnosis and progression monitoring of bone metastasis in lung cancer.BMC cancer · 2020Observational
- Practical Vitamin D Supplementation Using Machine Learning.Journal of bone metabolism · 2020Article
- Article
- Advanced Black Phosphorus Nanomaterials for Bone Regeneration.International journal of nanomedicine · 2020Review
- Predicting the Incidence and Prognosis of Bone Metastatic Breast Cancer: A SEER-Based Observational Study.BioMed research international · 2020Observational
- In Vitro 3D Cultures to Reproduce the Bone Marrow Niche.JBMR plus · 2019Review
- Atypical femoral fractures from bisphosphonate in cancer patients - Review.Journal of bone oncology · 2019Review
- Bisphosphonate use in the horse: what is good and what is not?BMC veterinary research · 2019Article
- PMMA-FeTheranostics · 2019Article
- Hallmarks of Bone Metastasis.Calcified tissue international · 2018Review
- PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Bone Cell Bioenergetics and Skeletal Energy Homeostasis.Physiological reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the context of breast cancer, the importance of the skeleton in the regulation of primary tumour development and as a site for subsequent metastasis is well characterized. Our understanding of the contributions made by the host bone and bone marrow cells increasingly demonstrates the extent of the interaction between tumour cells and normal host cells. As a result, the need to develop and utilize therapies that can impede the growth and/or function of tumour cells while sparing normal host bone and bone marrow cells is immense and expanding. The need for these new treatments is, however, superimposed on the orthopaedic management of patients' quality of life, where pain control and continued locomotion are paramount. Indeed, the majority of the anticancer therapies used to date often result in direct or indirect damage to bone. Thus, although the bone microenvironment regulates tumour cell growth in bone, cells within the bone marrow niche also mediate many of the orthopaedic consequences of tumour progression as well as resistance to the antitumour effects of existing therapies. In this Review, we highlight the effects of existing cancer treatments on bone and the bone marrow microenvironment as well as the mechanisms mediating these effects and the current utility of modern orthopaedic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.