Evidence map›Paper›PMID 26503649›Full record

ArticleAntimicrobial agents and chemotherapy2016

Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins.

Maria Siopi, Efthymios Neroutsos, Kalliopi Zisaki, Maria Gamaletsou, Maria Pirounaki, Panagiotis Tsirigotis, Nikolaos Sipsas, Aristides Dokoumetzidis, Evgenios Goussetis, Loukia Zerva and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Antifungal Combinations againstJournal of fungi (Basel, Switzerland) · 2022
    Review
  3. Studies in mycology · 2021
    Review
  4. Article
  5. Article
  6. Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2018
    Review
  7. Reply to "Agar Bioassays for Antifungals in Combination Therapy".Antimicrobial agents and chemotherapy · 2016
    Article
  8. Agar Bioassays for Antifungals in Combination Therapy.Antimicrobial agents and chemotherapy · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria SiopiClinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Efthymios NeroutsosLaboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Kalliopi ZisakiBone Marrow Transplantation Unit, Aghia Sophia Children Hospital, Athens, Greece.
Maria GamaletsouPathophysiology Department, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Maria Pirounaki2nd Department of Internal Medicine, Hematology Unit, Ippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis Tsirigotis2nd Department of Internal Medicine, Hematology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos SipsasPathophysiology Department, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Aristides DokoumetzidisLaboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Evgenios GoussetisBone Marrow Transplantation Unit, Aghia Sophia Children Hospital, Athens, Greece.
Loukia ZervaClinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgia ValsamiLaboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Joseph MeletiadisClinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece jmeletiadis@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voriconazole levels were determined with high-performance liquid chromatography (HPLC) and a microbiological agar diffusion assay using a Candida parapsilosis isolate in 103 serum samples from an HPLC-tested external quality control program (n = 39), 21 patients receiving voriconazole monotherapy (n = 39), and 7 patients receiving combination therapy (n = 25). The results of the bioassay were correlated with the results obtained from the external quality control program samples and with the HPLC results in sera from patients on voriconazole monotherapy and on combination therapy with an echinocandin (Spearman's rank correlation coefficient [rs], > 0.93; mean ± standard error of the mean [SEM] % difference, <12% ± 3.8%).

Indexed as

Biological AssayAntifungal AgentsCandidaCandidiasisChromatography, High Pressure LiquidColony Count, MicrobialDrug Therapy, CombinationEchinocandinsHumansQuality ControlRegression AnalysisReproducibility of ResultsSensitivity and SpecificityVoriconazoleAntifungal AgentsEchinocandinsVoriconazole

Identifiers

PMID26503649
PMCPMC4704192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.