Evidence map›Paper›PMID 26503640›Full record

ArticleLab on a chip2015

Precision chemical heating for diagnostic devices.

J R Buser, S Diesburg, J Singleton, D Guelig, J D Bishop, C Zentner, R Burton, P LaBarre, P Yager, B H Weigl

Open access · hybridAbstract read
In one paragraph

Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. DetectingJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020
    Article
  6. Tunable and precise miniature lithium heater for point-of-care applications.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

J R BuserDepartment of Bioengineering, University of Washington, Box 355061, Seattle, WA, USA. buserj@uw.edu.
S DiesburgPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
J SingletonPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
D GueligPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
J D BishopDepartment of Bioengineering, University of Washington, Box 355061, Seattle, WA, USA. buserj@uw.edu.
C ZentnerPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
R BurtonPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
P LaBarrePATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
P YagerDepartment of Bioengineering, University of Washington, Box 355061, Seattle, WA, USA. buserj@uw.edu.
B H WeiglPATH: The Program for Appropriate Technology in Healthcare, Seattle, WA, USA.
Seattle University · USProgram for Appropriate Technology in Health · INProgram for Appropriate Technology in Health · USUniversity of Washington · US

Funding

CaO-heated DNA amplification obviates electricity requirement at point of careR01EB012641 · NIBIB · PATH · PI BURTON, ROBERT ANDREW · 2011 to 2013
$1.8M
Recombinase Polymerase Amplification for Point-of-Care Diagnosis of Infant HIV-1R01AI097038 · NIAID · PATH · PI BOYLE, DAVID SCOTT · 2011 to 2013
$1.2M
NIAID NIH HHS R01 AI097038NIAID NIH HHS R01AI097038NIBIB NIH HHS R01 EB012641NIBIB NIH HHS R01EB012641
6 · The paper itself

Abstract

Decoupling nucleic acid amplification assays from infrastructure requirements such as grid electricity is critical for providing effective diagnosis and treatment at the point of care in low-resource settings. Here, we outline a complete strategy for the design of electricity-free precision heaters compatible with medical diagnostic applications requiring isothermal conditions, including nucleic acid amplification and lysis. Low-cost, highly energy dense components with better end-of-life disposal options than conventional batteries are proposed as an alternative to conventional heating methods to satisfy the unique needs of point of care use.

Indexed as

HeatingDiagnostic Techniques and ProceduresElectric Power SuppliesEquipment DesignNucleic Acid Amplification TechniquesPoint-of-Care Systems

Identifiers

PMID26503640
PMCPMC10249953
OpenAlexW1880968444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.