ArticleBMC genetics2015
Genome-wide evolutionary and functional analysis of the Equine Repetitive Element 1: an insertion in the myostatin promoter affects gene expression.
Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Research Trends and Emerging Frontiers in Racehorse Genetics: A Bibliometric Analysis.Animals : an open access journal from MDPI · 2026Article
- TEPEAK: A novel method for identifying and characterizing polymorphic transposable elements in non-model species populations.PLoS computational biology · 2026Article
- CENP-A and centromere evolution in equids.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- Transposon expression and repression in skeletal muscle.Mobile DNA · 2025Review
- The Effect of Selection on the Two Important Myostatin Gene Mutations in the Dareshouri Horse in the Middle East.Veterinary medicine and science · 2025Article
- CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids.Genome biology · 2025Article
- Ere, a Family of Short Interspersed Elements in the Genomes of Odd-Toed Ungulates (Perissodactyla).Animals : an open access journal from MDPI · 2024Article
- A Satellite-Free Centromere inInternational journal of molecular sciences · 2023Article
- Refining theAnimals : an open access journal from MDPI · 2022Article
- Molecular Dynamics and Evolution of Centromeres in the Genus Equus.International journal of molecular sciences · 2022Review
- A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses.Scientific reports · 2021Article
- Insertion of Telomeric Repeats in the Human and Horse Genomes: An Evolutionary Perspective.International journal of molecular sciences · 2020Article
- Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.Animal genetics · 2019Review
- CENP-A binding domains and recombination patterns in horse spermatocytes.Scientific reports · 2019Article
- Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation.Journal of animal science and biotechnology · 2019Review
- Effect of selection for eventing on theJournal of equine science · 2018Article
- The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion.PloS one · 2018Article
- Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology.Scientific reports · 2017Article
- The major horse satellite DNA family is associated with centromere competence.Molecular cytogenetics · 2016Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn mammals, an important source of genomic variation is insertion polymorphism of retrotransposons. These may acquire a functional role when inserted inside genes or in their proximity. The aim of this work was to carry out a genome wide analysis of ERE1 retrotransposons in the horse and to analyze insertion polymorphism in relation to evolution and function. The effect of an ERE1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.
resultsIn the horse population, the fraction of ERE1 polymorphic loci is related to the degree of similarity to their consensus sequence. Through the analysis of ERE1 conservation in seven equid species, we established that the level of identity to their consensus is indicative of evolutionary age of insertion. The position of ERE1s relative to genes suggests that some elements have acquired a functional role. Reporter gene assays showed that the ERE1 insertion within the horse myostatin promoter affects gene expression. The frequency of this variant promoter correlates with sport aptitude and racing performance.
conclusionsSequence conservation and insertion polymorphism of ERE1 elements are related to the time of their appearance in the horse lineage, therefore, ERE1s are a useful tool for evolutionary and population studies. Our results suggest that the ERE1 insertion at the myostatin locus has been unwittingly selected by breeders to obtain horses with specific racing abilities. Although a complex combination of environmental and genetic factors contributes to athletic performance, breeding schemes may take into account ERE1 insertion polymorphism at the myostatin promoter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.