ArticleNeurocritical care2016
Hematoma Locations Predicting Delirium Symptoms After Intracerebral Hemorrhage.
Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Pooled it
- Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review.Critical care medicine · 2018Pooled it
- Predictive Factors in Development of Postoperative Delirium in Chronic Subdural Hematomas: A Prospective Multicenter Study.Journal of clinical medicine · 2026Article
- Occurrence Rates of Delirium in Brain Tumor Patients: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Research progress of postoperative delirium in neurosurgery.World journal of psychiatry · 2025Review
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- Risk factors for delirium occurring after deep brain stimulation surgery in patients with Parkinson's disease.Acta neurochirurgica · 2024Article
- Article
- Delirium and Its Associations with Critical Care Utilizations and Outcomes at the Time of Hospital Discharge in Patients with Acute Brain Injury.Medicina (Kaunas, Lithuania) · 2024Article
- Spatial normalization for voxel-based lesion symptom mapping: impact of registration approaches.Frontiers in neuroscience · 2024Article
- Management of delirium in acute stroke patients: a position paper by the Austrian Stroke Society on prevention, diagnosis, and treatment.Therapeutic advances in neurological disorders · 2024Review
- Association of delirium and spatial neglect in patients with right-hemisphere stroke.PM & R : the journal of injury, function, and rehabilitation · 2023Article
- Delirium After Traumatic Brain Injury: Prediction by Location and Size of Brain Lesion.Annals of rehabilitation medicine · 2023Article
- Article
- The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage.Neurology · 2020Article
- A Human Depression Circuit Derived From Focal Brain Lesions.Biological psychiatry · 2019Article
- Delirium Screening and Management in Inpatient Rehabilitation Facilities.American journal of physical medicine & rehabilitation · 2018Review
- Prophylactic Seizure Medication and Health-Related Quality of Life After Intracerebral Hemorrhage.Critical care medicine · 2018Article
- Delirium and topographical disorientation associated with glioblastoma multiforme tumour progression into the isthmus of the cingulate gyrus.BMJ case reports · 2018Article
- Delirium in Intensive Care Unit Patients: Ten Important Points of Understanding.Chinese medical journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDelirium symptoms are associated with later worse functional outcomes and long-term cognitive impairments, but the neuroanatomical basis for delirium symptoms in patients with acute brain injury is currently uncertain. We tested the hypothesis that hematoma location is predictive of delirium symptoms in patients with intracerebral hemorrhage, a model disease where patients are typically not sedated or bacteremic.
methodsWe prospectively identified 90 patients with intracerebral hemorrhage who underwent routine twice-daily screening for delirium symptoms with a validated examination. Voxel-based lesion-symptom mapping with acute computed tomography was used to identify hematoma locations associated with delirium symptoms (N = 89).
resultsAcute delirium symptoms were predicted by hematoma of right-hemisphere subcortical white matter (superior longitudinal fasciculus) and parahippocampal gyrus. Hematoma including these locations had an odds ratio for delirium of 13 (95 % CI 3.9-43.3, P < 0.001). Disruption of large-scale brain networks that normally support attention and conscious awareness was thus associated with acute delirium symptoms.
conclusionsHigher odds ratio for delirium was increased due to hematoma location. The location of neurological injury could be of high prognostic value for predicting delirium symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.