Evidence map›Paper›PMID 26503488›Full record

ArticleJournal of medical imaging and radiation oncology2015

Feasibility study for assessing liver fibrosis in paediatric and adolescent patients using real-time shear wave elastography.

Manish Dhyani, Michael S Gee, Joseph Misdraji, Esther Jacobowitz Israel, Uzma Shah, Anthony E Samir

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical imaging and radiation oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02086708 (Sonoelastography), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02086708 naterminatednot on this map

Sonoelastography: Ultrasound Method to Measure Fibrosis of the Liver in Children

TypeinterventionalSponsorMassachusetts General HospitalRan2010 to 2015Enrolled24ConditionsChronic Liver Disease, Non-Alcoholic Fatty Liver Disease, HCV Coinfection, HBVArmsShear Wave sonoelastography
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Observational
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  13. Principles of ultrasound elastography.Abdominal radiology (New York) · 2018
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manish DhyaniDepartment of Radiology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.
Michael S GeeDepartment of Radiology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.
Joseph MisdrajiDepartment of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.
Esther Jacobowitz IsraelDepartment of Pediatrics, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.
Uzma ShahDepartment of Pediatrics, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.
Anthony E SamirDepartment of Radiology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, Massachusetts, USA.

Funding

Reducing Variability in Hepatic Shear Wave ElastographyK23EB020710 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI SAMIR, ANTHONY EDWARD · 2016 to 2019
$781k
NIBIB NIH HHS K23 EB020710
6 · The paper itself

Abstract

introductionThe objective of this study was to evaluate the feasibility of shear wave elastography (SWE), as a non-invasive means of assessing liver fibrosis stage in paediatric and adolescent patients. MATERIALS AND

methodsConsecutive paediatric and adolescent subjects scheduled for liver biopsy (LB) evaluation of known or suspected diffuse liver disease were included after informed guardian consent and subject assent in this IRB-approved single institution study. Elastograms were acquired prior to liver biopsy, from the liver under a breath-hold after normal inspiration when possible. Biopsy specimens underwent blinded pathologist review using the METAVIR scoring system.

resultsTwenty-four patients (M : F = 13:11) with a mean age of 17 years (range: 1-21 years) underwent liver biopsy. The distribution of fibrosis on pathological examination was: F0 = 10, F1 = 9, F2 = 1, F3 = 3, and F4 = 1. Subjects with stages F0 and F1 fibrosis had a mean SWE value of 6.93 kPa (95% CI: 6.33-7.44 kPa) and 8.33 kPa (95% CI: 6.83-10.80 kPa) respectively. The SWE value for the one subject with stage F2 fibrosis was 6.36 kPa, whereas for F3 and F4 were 8.86 (95% CI: 5.70-11.40) and 17.85 kPa respectively. The correlation between SWE values and fibrosis grade was strong (r = 0.58, P = 0.003), and the area under the ROC curve differentiatiang ≥F2 fibrosis was 0.62 (95% CI: 0.26-0.98).

conclusionEstimation of liver stiffness using real-time SWE is feasible using the SC6-1 ultrasound probe in paediatric and adolescent patients and strongly correlates with the stage of fibrosis.

Indexed as

AdolescentChildChild, PreschoolComputer SystemsElasticity Imaging TechniquesFeasibility StudiesFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedInfantLiverLiver CirrhosisMaleObserver VariationReproducibility of Resultsliver biopsyliver fibrosisliver stiffnessshear wave elastographyultrasound

Identifiers

PMID26503488
PMCPMC7474553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.