Trial reportBMJ open2015
Protocol for the Care-IS Trial: a randomised controlled trial of a supportive educational intervention for carers of patients with high-grade glioma (HGG).
Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Benefits of supportive strategies for carers of people with high-grade glioma: a systematic review : Strategies for addressing the needs of high-grade glioma carers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Interventions to help support caregivers of people with a brain or spinal cord tumour.The Cochrane database of systematic reviews · 2019Pooled it
- Unmet care needs of advanced cancer patients and their informal caregivers: a systematic review.BMC palliative care · 2018Pooled it
- Carer preparedness improved by providing a supportive educational intervention for carers of patients with high-grade glioma: RCT results.Journal of neuro-oncology · 2023Trial
- The Clinical Value of High-Quality Nursing in Concurrent Radiotherapy and Chemotherapy after Glioma Surgery and Its Influence on the Stress Indicators Cor, ACTH, and CRP.Journal of healthcare engineering · 2022Trial
- Feasibility Testing and Refinement of a Supportive Educational Intervention for Carers of Patients with High-Grade Glioma - a Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Trial
- Nurse-identified needs, recommendations, and referrals during consultations with family carers of patients diagnosed with high-grade glioma.Neuro-oncology practice · 2025Article
- Identifying components of care coordination for primary brain tumor: A scoping review.Neuro-oncology practice · 2025Review
- Out-of-pocket costs for patients diagnosed with high-grade glioma and their carers.Neuro-oncology practice · 2025Article
- Development of a brief screening measure of unmet supportive care needs (SCNS-P&C-6) in caregivers of people with high-grade glioma.Journal of patient-reported outcomes · 2025Article
- A nurse-led intervention for carers of people with high-grade glioma: A case series of carers reporting high distress.Neuro-oncology practice · 2024Article
- Clinician perspectives on integrating neuro-oncology and palliative care for patients with high-grade glioma.Neuro-oncology practice · 2024Article
- What do carers of people with high-grade glioma perceive could improve their preparedness to care, and what additional support do they require?Neuro-oncology practice · 2024Article
- Exploratory multi-methods evaluation of an online intervention for carers of people with high-grade glioma.Neuro-oncology practice · 2023Article
- Determining the Research Priorities for Adult Primary Brain Tumours in Australia and New Zealand: A Delphi Study with Consumers, Health Professionals, and Researchers.Current oncology (Toronto, Ont.) · 2022Article
- Brain cancer patients' levels of distress and supportive care needs over time.Psycho-oncology · 2022Article
- An emotional roller coaster - family members' experiences of being a caregiver throughout a cancer trajectory.International journal of qualitative studies on health and well-being · 2022Article
- I-CoPE: A pilot study of structured supportive care delivery to people with newly diagnosed high-grade glioma and their carers.Neuro-oncology practice · 2019Article
- Do carer's levels of unmet needs change over time when caring for patients diagnosed with high-grade glioma and how are these needs correlated with distress?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHigh-grade glioma (HGG) is a rapidly progressive and debilitating disease. Primary carers experience significant levels of distress which impacts on their experience of caregiving, the quality of care received and the community in terms of the increased reliance on healthcare due to the potential development of complicated grief. This paper describes the protocol for testing the efficacy and feasibility of an intervention for primary carers of patients with HGG in order to improve preparedness to care and reduce carer distress.
methodsRandomised controlled trial. The target population is carers of patients with HGG who are undergoing combined chemoradiotherapy. The intervention consists of 4 components: (1) initial telephone assessment of unmet needs of the carer, (2) tailoring of a personalised resource folder, (3) home visit, (4) ongoing monthly telephone contact and support for 12 months. The control arm will receive usual care. PRIMARY HYPOTHESIS: This intervention will improve preparedness for caring and reduce carer psychological distress. SECONDARY HYPOTHESIS: This intervention will reduce carer unmet needs. The longer term aim of the intervention is to reduce patient healthcare resource utilisation and, by doing so, reduce costs. Assessments will be obtained at baseline, 8 weeks post intervention, then 4, 6 and 12 months. Participants will also complete a healthcare utilisation checklist and proxy performance status which will be assessed at baseline and monthly. 240 carers will be recruited. The sample size is 180. Multilevel mixed effects regression models will be applied to test the effect of the intervention. ETHICS: Ethics approval has been gained from Curtin University and the participating sites. DISSEMINATION: Results will be reported in international peer-reviewed journals. TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registration (ACTRN)12612001147875.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.