ArticleCerebral cortex (New York, N.Y. : 1991)2017
Learning-Induced Metaplasticity? Associative Training for Early Odor Preference Learning Down-Regulates Synapse-Specific NMDA Receptors via mGluR and Calcineurin Activation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- From circuits to behavior: Amygdala dysfunction in fragile X syndrome.Frontiers in integrative neuroscience · 2023Review
- Behavioral Training Related Neurotransmitter Receptor Expression Dynamics in the Nidopallium Caudolaterale and the Hippocampal Formation of Pigeons.Frontiers in physiology · 2022Article
- Calcineurin Participation in Hebbian and Homeostatic Plasticity Associated With Extinction.Frontiers in cellular neuroscience · 2021Review
- NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition.Neural plasticity · 2018Review
- NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory.Scientific reports · 2016Article
- CaMKII mediates stimulus specificity in early odor preference learning in rats.Journal of neurophysiology · 2016Article
- Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Development of Odor Hedonics: Experience-Dependent Ontogeny of Circuits Supporting Maternal and Predator Odor Responses in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rat pups readily form a 24-h associative odor preference after a single trial of odor paired with intermittent stroking. Recent evidence shows that this training trial, which normally increases AMPA receptor responses in the anterior piriform cortex both 3 and 24 h following training, induces a down-regulation of NMDA receptors 3 h later followed by NMDA receptor up-regulation at 24 h. When retrained with the same odor at 3 h, rat pups unlearn the original odor preference. Unlearning can be prevented by blocking NMDA receptors during retraining. Here, the mechanisms that initiate NMDA receptor down-regulation are assessed. Blocking mGluR receptors or calcineurin during training prevents down-regulation of NMDA receptors 3 h following training. Blocking NMDA receptors during training does not affect NMDA receptor down-regulation. Thus, down-regulation can be engaged separately from associative learning. When unlearning occurs, AMPA and NMDA receptor levels at 24 h are reset to control levels. Calcineurin blockade during retraining prevents unlearning consistent with the role of NMDA receptor down-regulation. The relationship of these events to the metaplasticity and plasticity mechanisms of long-term depression and depotentiation is discussed. We suggest a possible functional role of NMDA receptor down-regulation in offline stabilization of learned odor representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.