ArticleCerebral cortex (New York, N.Y. : 1991)2017
Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord.Scientific reports · 2024Article
- Article
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Olfactory Optogenetics: Light Illuminates the Chemical Sensing Mechanisms of Biological Olfactory Systems.Biosensors · 2021Review
- Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.Cell reports · 2021Article
- Sequential pattern of sublayer formation in the paleocortex and neocortex.Medical molecular morphology · 2020Article
- Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.eLife · 2020Article
- Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing.Frontiers in physiology · 2020Review
- Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- Pre- and Postsynaptic Activation of GABAFrontiers in cellular neuroscience · 2018Article
- Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex.Scientific reports · 2017Article
- Spontaneous activity in the piriform cortex extends the dynamic range of cortical odor coding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types.eLife · 2016Article
- Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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- Review
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Despite its comparatively simple trilaminar architecture, the primary olfactory (piriform) cortex of mammals is capable of performing sophisticated sensory processing, an ability that is thought to depend critically on its extensive associational (intracortical) excitatory circuits. Here, we used a novel transgenic mouse model and optogenetics to measure the connectivity of associational circuits that originate in semilunar (SL) cells in layer 2a of the anterior piriform cortex (aPC). We generated a mouse line (48L) in which channelrhodopsin-2 (ChR) could be selectively expressed in a subset of SL cells. Light-evoked excitatory postsynaptic currents (EPSCs) could be evoked in superficial pyramidal cells (17.4% of n = 86 neurons) and deep pyramidal cells (33.3%, n = 9) in the aPC, but never in ChR- SL cells (0%, n = 34). Thus, SL cells monosynaptically excite pyramidal cells, but not other SL cells. Light-evoked EPSCs were also selectively elicited in 3 classes of GABAergic interneurons in layer 3 of the aPC. Our results show that SL cells are specialized for providing feedforward excitation of specific classes of neurons in the aPC, confirming that SL cells comprise a functionally distinctive input layer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.