ArticleScientific reports2015
Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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Who cites it
119 citing papers in PubMed.
- Deep Learning-Based Inclusion Boundary Identification Using Wave Propagation in Optical Coherence Elastography.Journal of biophotonics · 2026Article
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- In vivo biomechanical property detection of the ciliary muscle based on optical coherence tomography and digital image correlation technology.Eye and vision (London, England) · 2026Article
- Protocol to study murine ovarian elasticity and composition in situ by integrating quantitative micro-elastography with light microscopy.STAR protocols · 2026Article
- Optical coherence tomography and elastography forJournal of biomedical optics · 2026Article
- Development of breast-mimicking phantoms for use in optical coherence elastography.Journal of biomedical optics · 2025Article
- Noninvasive quantitative assessment of oral submucosal fibrosisJournal of biomedical optics · 2025Article
- Diagnostic feasibility study of stereoscopic optical palpation for breast tumour margin assessment.BMC cancer · 2025Article
- Three-dimensional quantitative micro-elastography reveals alterations in spatial elasticity patterns in murine ovaries during ageing.Communications biology · 2025Article
- Three-dimensional dynamic optical coherence tomography for breast tumor margin assessment.Biomedical optics express · 2025Article
- Wide-field quantitative micro-elastography of freshly excised human prostate.Biomedical optics express · 2025Article
- Convolutional Neural Networks Enable Direct Strain Estimation in Quasistatic Optical Coherence Elastography.Journal of biophotonics · 2025Article
- Tissue stiffness mapping by light sheet elastography.Science advances · 2025Article
- Design and characterization of an optical phantom for mesoscopic multimodal fluorescence lifetime imaging and optical coherence elastography.Biomedical optics express · 2025Article
- A co-registration method to validateHeliyon · 2025Article
- Imaging of prostate micro-architecture using three-dimensional wide-field optical coherence tomography.Biomedical optics express · 2024Article
- Near-infrared spectroscopy-enabled electromechanical systems for fast mapping of biomechanics and subcutaneous diagnosis.Science advances · 2024Article
- Geophysics-Inspired Nonlinear Stress-Strain Law for Biological Tissues and Its Applications in Compression Optical Coherence Elastography.Materials (Basel, Switzerland) · 2024Article
- Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2024Article
- A novel stress sensor enables accurate estimation of micro-scale tissue mechanics in quantitative micro-elastography.APL bioengineering · 2024Article
59 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Probing the mechanical properties of tissue on the microscale could aid in the identification of diseased tissues that are inadequately detected using palpation or current clinical imaging modalities, with potential to guide medical procedures such as the excision of breast tumours. Compression optical coherence elastography (OCE) maps tissue strain with microscale spatial resolution and can delineate microstructural features within breast tissues. However, without a measure of the locally applied stress, strain provides only a qualitative indication of mechanical properties. To overcome this limitation, we present quantitative micro-elastography, which combines compression OCE with a compliant stress sensor to image tissue elasticity. The sensor consists of a layer of translucent silicone with well-characterized stress-strain behaviour. The measured strain in the sensor is used to estimate the two-dimensional stress distribution applied to the sample surface. Elasticity is determined by dividing the stress by the strain in the sample. We show that quantification of elasticity can improve the ability of compression OCE to distinguish between tissues, thereby extending the potential for inter-sample comparison and longitudinal studies of tissue elasticity. We validate the technique using tissue-mimicking phantoms and demonstrate the ability to map elasticity of freshly excised malignant and benign human breast tissues.
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