ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- The genomic landscape of the immune system in lung cancer: present insights and continuing investigations.Frontiers in genetics · 2024Review
- Urbanization drives adaptive evolution in a Neotropical bird.Current zoology · 2023Article
- Role of microRNA-494 in tumor progression.American journal of translational research · 2023Review
- Hsa_circRNA_0017620 regulated cell progression of non-small-cell lung cancer via miR-520a-5p/KRT5 axis.Journal of clinical laboratory analysis · 2022Article
- Sweet Control: MicroRNA Regulation of the Glycome.Biochemistry · 2020Review
- MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7.Technology in cancer research & treatment · 2018Article
- miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.Digestive diseases and sciences · 2017Article
- MicroRNA-30e Functions as a Tumor Suppressor in Cervical Carcinoma Cells through Targeting GALNT7.Translational oncology · 2017Article
- Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma.Oncotarget · 2017Article
- Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability.EBioMedicine · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. However, the role of GALNT7 in the development and progression of nasopharyngeal carcinoma (NPC) remains unclear. Our previous study showed that GALNT7 was a putative target of miR-494, which was confirmed by luciferase reporter assay. In the present study, we demonstrated that in vitro knockdown of GALNT7 significantly inhibited the proliferation, colony formation, migration, and invasion of NPC-derived cells. In vivo tumorigenicity assay showed that miR-494 and GALNT7-small interfering RNA (siRNA) reduced tumor growth in nude mice. Taken together, our results provided new evidence for an oncogenic role of GALNT7 in NPC.
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