ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
The Role of Stage at Diagnosis in Colorectal Cancer Black-White Survival Disparities: A Counterfactual Causal Inference Approach.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.Cancer causes & control : CCC · 2024Pooled it
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- A Review of the Causal Decomposition Framework for Modeling Interventions that Reduce Disparities.Current epidemiology reports · 2025Article
- Mediation analysis using incomplete information from publicly available data sources.Statistics in medicine · 2024Article
- Survival Disparities among Cancer Patients Based on Mobility Patterns: A Population-Based Study.Health data science · 2024Article
- Recommendations for Using Causal Diagrams to Study Racial Health Disparities.American journal of epidemiology · 2022Article
- Bayesian data fusion: Probabilistic sensitivity analysis for unmeasured confounding using informative priors based on secondary data.Biometrics · 2022Article
- The role of body mass index at diagnosis of colorectal cancer on Black-White disparities in survival: a density regression mediation approach.Biostatistics (Oxford, England) · 2022Article
- Bias Issues in Colorectal Cancer Management: A Review.Annals of surgical oncology · 2022Review
- Disparities in Surgical Oncology: Management of Advanced Cancer.Annals of surgical oncology · 2021Review
- Age-dependent prognostic value ofFuture oncology (London, England) · 2021Article
- Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models.BMC medical research methodology · 2021Article
- Examining COVID-19 Preventive Behaviors among Cancer Survivors in the United States: An Analysis of the COVID-19 Impact Survey.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- The Impact of KRAS Mutation on the Presentation and Prognosis of Non-Metastatic Colon Cancer: an Analysis from the National Cancer Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- The contribution of residential greenness to mortality among men with prostate cancer: a registry-based cohort study of Black and White men.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Invited Commentary: Making Causal Inference More Social and (Social) Epidemiology More Causal.American journal of epidemiology · 2020Article
- Trends in Sociodemographic Disparities in Colorectal Cancer Staging and Survival: A SEER-Medicare Analysis.Clinical and translational gastroenterology · 2020Article
- The role of socioeconomic disparity in colorectal cancer stage at presentation.Updates in surgery · 2019Article
- How do we assess a racial disparity in health? Distribution, interaction, and interpretation in epidemiological studies.Annals of epidemiology · 2019Article
- Socioeconomic and Tobacco Mediation of Ethnic Inequalities in Mortality over Time: Repeated Census-mortality Cohort Studies, 1981 to 2011.Epidemiology (Cambridge, Mass.) · 2018Article
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6 authors.
Funding
Abstract
backgroundTo date, a counterfactual framework has not been used to study determinants of social inequalities in cancer. Considering the case of colorectal cancer, for which racial/ethnic differences in stage at diagnosis and survival are well documented, we quantify the extent to which black versus white survival disparities would be reduced had disparities in stage at diagnosis been eliminated in a large patient population.
methodsWe obtained data on colorectal cancer patients (diagnosed between 1992 and 2005 and followed until 2010) from US-SEER (Surveillance, Epidemiology, and End Results) cancer registries. We employed a counterfactual approach to estimate the mean survival time up to the 60th month since diagnosis for black colorectal cancer patients had black-white disparities in stage at diagnosis been eliminated.
resultsBlack patients survive approximately 4.0 [confidence interval (CI), 4.6-3.2] months less than white patients within five years since diagnosis. Had disparities in stage at diagnosis been eliminated, survival disparities decrease to 2.6 (CI, 3.4-1.7) months, an approximately 35% reduction. For patients diagnosed after the age of 65 years, disparities would be halved, while reduction of approximately 30% is estimated for younger patients. Survival disparities would be reduced by approximately 44% for women and approximately 26% for men.
conclusionsEmploying a counterfactual approach and allowing for heterogeneities in black-white disparities across patients' characteristics, we give robust evidence that elimination of disparities in stage at diagnosis contributes to a substantial reduction in survival disparities in colorectal cancer. IMPACT: We provide the first evidence in the SEER population that elimination of inequities in stage at diagnosis might lead to larger reductions in survival disparities among elderly and women.
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