ArticleHuman brain mapping2016
Impaired prefrontal synaptic gain in people with psychosis and their relatives during the mismatch negativity.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism.Autism research : official journal of the International Society for Autism Research · 2026Article
- Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis.Nature. Mental health · 2026Article
- Mismatch negativity develops in adolescence and independently of microglia.bioRxiv : the preprint server for biology · 2025Article
- Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms.medRxiv : the preprint server for health sciences · 2025Article
- A detailed theory of thalamic and cortical microcircuits for predictive visual inference.Science advances · 2025Article
- Model-Based Approaches to Investigating Mismatch Responses in Schizophrenia.Clinical EEG and neuroscience · 2025Review
- A computational account of joint SSRI and anti-inflammatory treatment.Frontiers in immunology · 2025Article
- Children at Familial High risk of Schizophrenia and Bipolar Disorder Exhibit Altered Connectivity Patterns During Pre-attentive Processing of an Auditory Prediction Error.Schizophrenia bulletin · 2024Article
- Why mismatch negativity continues to hold potential in probing altered brain function in schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2023Review
- The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers.Scientific reports · 2023Article
- Computational Modeling of Oddball Sequence Processing Exposes Common and Differential Auditory Network Changes in First-Episode Schizophrenia-Spectrum Disorders and Schizophrenia.Schizophrenia bulletin · 2023Article
- A parahippocampal-sensory Bayesian vicious circle generates pain or tinnitus: a source-localized EEG study.Brain communications · 2023Article
- Amygdala connectivity related to subsequent stress responses during the COVID-19 outbreak.Frontiers in psychiatry · 2023Article
- Somatosensory Evoked Potentials Reveal Reduced Embodiment of Emotions in Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neurophysiology in psychosis: The quest for disease biomarkers.Translational psychiatry · 2022Review
- GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia.Biological psychiatry · 2022Article
- Toward biophysical markers of depression vulnerability.Frontiers in psychiatry · 2022Article
- Mismatch negativity amplitude in first-degree relatives of individuals with psychotic disorders: Links with cognition and schizotypy.Schizophrenia research · 2021Article
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Authors and funding
15 authors at 10 institutions in 5 countries.
Funding
Abstract
The mismatch negativity (MMN) evoked potential, a preattentive brain response to a discriminable change in auditory stimulation, is significantly reduced in psychosis. Glutamatergic theories of psychosis propose that hypofunction of NMDA receptors (on pyramidal cells and inhibitory interneurons) causes a loss of synaptic gain control. We measured changes in neuronal effective connectivity underlying the MMN using dynamic causal modeling (DCM), where the gain (excitability) of superficial pyramidal cells is explicitly parameterised. EEG data were obtained during a MMN task--for 24 patients with psychosis, 25 of their first-degree unaffected relatives, and 35 controls--and DCM was used to estimate the excitability (modeled as self-inhibition) of (source-specific) superficial pyramidal populations. The MMN sources, based on previous research, included primary and secondary auditory cortices, and the right inferior frontal gyrus. Both patients with psychosis and unaffected relatives (to a lesser degree) showed increased excitability in right inferior frontal gyrus across task conditions, compared to controls. Furthermore, in the same region, both patients and their relatives showed a reversal of the normal response to deviant stimuli; that is, a decrease in excitability in comparison to standard conditions. Our results suggest that psychosis and genetic risk for the illness are associated with both context-dependent (condition-specific) and context-independent abnormalities of the excitability of superficial pyramidal cell populations in the MMN paradigm. These abnormalities could relate to NMDA receptor hypofunction on both pyramidal cells and inhibitory interneurons, and appear to be linked to the genetic aetiology of the illness, thereby constituting potential endophenotypes for psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.