Evidence map›Paper›PMID 26502923›Full record

ArticlePathology oncology research : POR2016

Clinicopathological Variation of Lauren Classification in Gastric Cancer.

Yun-Chi Chen, Wen-Liang Fang, Ruei-Fang Wang, Chien-An Liu, Muh-Hwa Yang, Shu-Shun Lo, Chew-Wen Wu, Anna Fen-Yau Li, Yi-Ming Shyr, Kuo-Hung Huang

Abstract read
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In one paragraph

Article in Pathology oncology research : POR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pattern of lymph node metastases in gastric cancer: a side-study of the multicenter LOGICA-trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022
    Trial
  5. Intratumoral and peritumoral radiomics analysis for preoperative Lauren classification in gastric cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020
    Trial
  6. Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis.Oxidative medicine and cellular longevity · 2017
    Trial
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  8. Review
  9. Article
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  15. Review
  16. Article
  17. Article
  18. Nomogram Prediction for Gastric Cancer Development.Clinical and translational gastroenterology · 2025
    Article
  19. Review
  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun-Chi ChenDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.
Wen-Liang FangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.
Ruei-Fang WangDepartment of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chien-An LiuSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Muh-Hwa YangInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Shu-Shun LoSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chew-Wen WuDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.
Anna Fen-Yau LiSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yi-Ming ShyrDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.
Kuo-Hung HuangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China. khhuang@vghtpe.gov.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren's classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren's classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren's classification, 1423(46.3%) patients were intestinal type, 1000 patients (32.6%) were diffuse type, and 648 patients (21.1%) were mixed type. The clinicopathological characteristics and prognosis in Lauren's classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7%) had a better 5-year overall survival than diffuse type (45.6%) and mixed type (43.4%, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming's histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren's classification (P = 0.003) were significant correlated in gastric cancer. Lauren's classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren's classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.

Indexed as

GastrectomyAdenocarcinomaAgedFemaleFollow-Up StudiesHumansIntestinal NeoplasmsMaleNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingPrognosisStomach NeoplasmsSurvival RateGastrecotomyGastric cancerLauren’s classification

Identifiers

PMID26502923

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.