ArticleInfection and immunity2016
The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 123 citations in OpenAlex.
- Article
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- Ilimaquinone as a novel marine sponge-derived antibacterial agent: mechanistic insights into its antibiofilm and quorum sensing inhibitory properties targeting bacterial virulence.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
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- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- A conserved Phytophthora apoplastic trypsin-like serine protease targets the receptor-like kinase BAK1 to dampen plant immunity.Nature plants · 2025Article
- Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa.Journal of natural medicines · 2025Article
- Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability.Molecules (Basel, Switzerland) · 2025Review
- The relationship between virulence and drug resistance genes inFrontiers in cellular and infection microbiology · 2025Article
- Polymicrobial interactions betweenbioRxiv : the preprint server for biology · 2024Article
- Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa.The Journal of antibiotics · 2024Article
- Screening of the PA14NR Transposon Mutant Library Identifies Genes Involved in Resistance to Bacteriophage Infection inInternational journal of molecular sciences · 2024Article
- The Epistemology of Bacterial Virulence Factor Characterization.Microorganisms · 2024Review
- Cytotoxic rhamnolipid micelles drive acute virulence inInfection and immunity · 2024Article
- Discovery of Potential Anti-Microbial Molecules and Spectrum Correlation Effect ofMolecules (Basel, Switzerland) · 2024Article
- Article
- RNA target highlights in CASP15: Evaluation of predicted models by structure providers.Proteins · 2023Article
- The phage-encoded protein PIT2 impactsiScience · 2023Article
- Cytotoxic rhamnolipid micelles drive acute virulence inbioRxiv : the preprint server for biology · 2023Article
- Potassium Chloride, Sodium Lactate and Sodium Citrate Impaired the Antimicrobial Resistance and Virulence ofMolecules (Basel, Switzerland) · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The opportunistic pathogen Pseudomonas aeruginosa is capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library of P. aeruginosa PA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition. Our results indicate that the production of two proteases with anti-flagellin activity provides a failsafe mechanism for P. aeruginosa to ensure the maintenance of protease-dependent immune-modulating functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.