Evidence map›Paper›PMID 26502827›Full record

ArticleACS applied materials & interfaces2015

Impact of Mixed β-Cyclodextrin Ratios on Pluronic Rotaxanation Efficiency and Product Solubility.

Yawo A Mondjinou, Seok-Hee Hyun, Manxi Xiong, Christopher J Collins, Pooi Ling Thong, David H Thompson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. GdBioconjugate chemistry · 2018
    Article
  5. Article
  6. One-pot synthesis of block-copolyrotaxanes through controlledBeilstein journal of organic chemistry · 2017
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yawo A MondjinouMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
Seok-Hee HyunMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
Manxi XiongMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
Christopher J CollinsMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
Pooi Ling ThongMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
David H ThompsonMulti-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
Purdue University West Lafayette · USState Street (United States) · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Development of Long-circulating, Degradable Gd-Polyrotaxane MR AgentsR21EB017921 · NIBIB · PURDUE UNIVERSITY · PI THOMPSON, DAVID H · 2014 to 2015
$432k
NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1TR001108NCI NIH HHS CA23168NCI NIH HHS P30 CA023168NIBIB NIH HHS R21 EB017921
6 · The paper itself

Abstract

Water-soluble polyrotaxanes have been prepared under heterogeneous conditions from mixtures of β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin, or 6-monoazido-β-cyclodextrin with 4-sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and Pluronic L81 copolymer modified with cholesterol end caps. Threading reactions gave polyrotaxane products in modest chemical yield that were reflective of the β-CD feed ratios in the reaction. Polyrotaxanes containing mixtures of HP-β-CD and SBE-β-CD were screened and found to be biologically active in an in vitro model of Niemann-Pick Type C disease where they mobilize aberrantly stored cholesterol similarly to monomeric cyclodextrin controls.

Indexed as

2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsCholesterolCyclodextrinsFibroblastsHumansMicroscopy, Electron, TransmissionNiemann-Pick Disease, Type CPoloxamerPolymersRotaxanesSolubilityWater2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsbetadexCholesterolCyclodextrinsmethyl-beta-cyclodextrinPoloxamerPolymersRotaxanesSBE4-beta-cyclodextrinWateramorphous solidcyclodextrininclusion efficiencymacrocyclicmixed rotaxanationNiemann-Pick Type CPluronicpolyrotaxanesupramolecule

Identifiers

PMID26502827
PMCPMC4683156
OpenAlexW1843422304

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.