ArticleJournal of experimental & clinical cancer research : CR2015
Integrated analysis of genome-wide DNA methylation, gene expression and protein expression profiles in molecular subtypes of WHO II-IV gliomas.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma.Tomography (Ann Arbor, Mich.) · 2025Article
- Low-coverage and cost-effective whole-genome sequencing assay for glioma risk stratification.Journal of cancer research and clinical oncology · 2023Article
- Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas.NMR in biomedicine · 2023Review
- Identification of core differentially methylated genes in glioma.Oncology letters · 2019Article
- Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction.CNS neuroscience & therapeutics · 2019Article
- Hepatitis B Virus X Protein-Induced RORBioMed research international · 2019Article
- Hypermethylation of Secreted Frizzled Related Protein 1 gene promoter in different astrocytoma grades.Croatian medical journal · 2018Article
- G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity.Journal of neuro-oncology · 2018Article
- An immune-related lncRNA signature for patients with anaplastic gliomas.Journal of neuro-oncology · 2018Article
- Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma.Disease markers · 2017Article
- Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: advantages and pitfalls.Journal of experimental & clinical cancer research : CR · 2016Article
- The prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patients.Oncotarget · 2016Article
- A restricted signature of serum miRNAs distinguishes glioblastoma from lower grade gliomas.Journal of experimental & clinical cancer research : CR · 2016Article
- PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition.Journal of experimental & clinical cancer research : CR · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioma is the most common malignant primary brain tumor among adults, among which glioblastoma (GBM) exhibits the highest malignancy. Despite current standard chemoradiation, glioma is still invariably fatal. A further insight into the molecular background of glioma is required to improve patient outcomes.
methodPrevious studies evaluated molecular genetic differences through comparing different grades of glioma. Here, we integrated DNA methylation, RNA sequencing and protein expression data sets of WHO grade II to IV gliomas, to screen for dysregulated genes in subtypes during malignant progression of glioma.
resultsWe propose a list of universal genes (UG) as novel glioma biomarkers: 977 up-regulated genes and 114 down-regulated genes, who involved in cell cycle, Wnt receptor signaling pathway and fatty acid metabolic process. Poorer survival was associated significantly with the high expression of 977 up-regulated genes and low expression of 114 down-regulated in UG (P <0.001).
conclusionTo our knowledge, this was the first study that focused on subtypes to detect dysregulated genes that could contribute to malignant progression. Furthermore, the differentially expressed genes profile may lead to the identification of new therapeutic targets for glioma patients.
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