ArticleNature neuroscience2015
Trajectory events across hippocampal place cells require previous experience.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed.
- Hippocampal theta sweeps indicate goal direction during navigation.Nature neuroscience · 2026Article
- Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026Article
- Human hippocampal ripples tune cortical responses based on predicted uncertainty.Nature neuroscience · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Disrupted hippocampal replay is associated with reduced offline map stabilization in an Alzheimer's mouse model.Current biology : CB · 2026Article
- Effects of Novelty and Temporal Distance on Postexperience Spike Patterns of Hippocampal Place Cells Encoding Multiple Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Age and Self-Expansion Behaviors Correlate with Spatial Navigation in Healthy Adults.Brain sciences · 2025Article
- Competition and cooperation of assembly sequences in recurrent neural networks.PLoS computational biology · 2025Article
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- ThermoMaze behavioral paradigm for assessing immobility-related brain events in rodents.eLife · 2025Article
- Brain State-Dependent Neocortico-Hippocampal Network Dynamics Are Modulated by Postnatal Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Article
- Distinct mechanisms and functions of episodic memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Memory engram stability and flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Nested compressed co-representations of multiple sequential experiences during sleep.Nature neuroscience · 2024Article
31 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapped onto new experiences without learning sequential structure. Here we employed high density recording methods to monitor hundreds of place cells simultaneously while rats explored multiple novel environments. While we observed large numbers of synchronous spiking events before experience, they were not temporally correlated with subsequent experience. Multiple measures differentiated pre-experience and postexperience events that, taken together, defined the latter but not the former as trajectory-depicting. The formation of events with these properties was prevented by administration of an NMDA-receptor antagonist during experience. These results suggest that the sequential structure of behavioral episodes is encoded during experience and reexpressed as trajectory events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.