Evidence map›Paper›PMID 26502233›Full record

ArticleJournal of biomedical optics2015

Investigating the influence of chromatic aberration and optical illumination bandwidth on fundus imaging in rats.

Hao Li, Wenzhong Liu, Hao F Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hao LiNorthwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Wenzhong LiuNorthwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Hao F ZhangNorthwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United StatesbNorthwestern University, Department of Ophthalmology, 645 North Michigan Avenue, Chicago, Illinois 60611, United States.
Northwestern University · US

Funding

Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
Mechanisms of anterior segment development and corneal neovascularizationR01EY019484 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2010 to 2014
$1.5M
Howard Hughes Medical InstituteNEI NIH HHS 1R01EY019951NEI NIH HHS 1R24EY022883NEI NIH HHS 2R01EY019484NEI NIH HHS R01 EY019484NEI NIH HHS R01 EY019951NEI NIH HHS R24 EY022883
6 · The paper itself

Abstract

Abstract. Rodent models are indispensable in studying various retinal diseases. Noninvasive, high-resolution retinal imaging of rodent models is highly desired for longitudinally investigating the pathogenesis and therapeutic strategies. However, due to severe aberrations, the retinal image quality in rodents can be much worse than that in humans. We numerically and experimentally investigated the influence of chromatic aberration and optical illumination bandwidth on retinal imaging. We confirmed that the rat retinal image quality decreased with increasing illumination bandwidth. We achieved the retinal image resolution of 10  μm using a 19 nm illumination bandwidth centered at 580 nm in a home-built fundus camera. Furthermore, we observed higher chromatic aberration in albino rat eyes than in pigmented rat eyes. This study provides a design guide for high-resolution fundus camera for rodents. Our method is also beneficial to dispersion compensation in multiwavelength retinal imaging applications.

Indexed as

AlgorithmsArtifactsAlbinismAnimalsColorEquipment DesignEquipment Failure AnalysisFundus OculiImage EnhancementImage Interpretation, Computer-AssistedLightingRatsRats, Long-EvansRats, Sprague-DawleyReproducibility of ResultsRetina

Identifiers

PMID26502233
PMCPMC4881312
OpenAlexW1870600962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.