Trial reportJournal of addiction medicine
Effects of Prereactivation Propranolol on Cocaine Craving Elicited by Imagery Script/Cue Sets in Opioid-dependent Polydrug Users: A Randomized Study.
Trial report in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: a systematic review and meta-analysis of clinical and 'sub-clinical' studies.Psychopharmacology · 2018Pooled it
- Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers.Translational psychiatry · 2021Trial
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- New Approaches for Alcohol Use Disorder Treatment via Memory Retrieval and Reconsolidation Manipulations.Current topics in behavioral neurosciences · 2025Review
- Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review.Brain sciences · 2022Review
- Targeting the Reconsolidation of Licit Drug Memories to Prevent Relapse: Focus on Alcohol and Nicotine.International journal of molecular sciences · 2021Review
- Silent synapses dictate cocaine memory destabilization and reconsolidation.Nature neuroscience · 2020Article
- Counterconditioning following memory retrieval diminishes the reinstatement of appetitive memories in humans.Scientific reports · 2019Article
- Article
- Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Does human language limit translatability of clinical and preclinical addiction research?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Exacerbated Craving in the Presence of Stress and Drug Cues in Drug-Dependent Patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Observational
- Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse.Biological psychiatry · 2017Article
- Garcinol Blocks the Reconsolidation of Multiple Cocaine-Paired Cues after a Single Cocaine-Reactivation Session.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments.Neurobiology of learning and memory · 2017Review
- Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving.JAMA psychiatry · 2017Article
- Response to: "Updated and rectified meta-analysis shows no effect of propranolol versus placebo on traumatic memory reconsolidation disruption".Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesRelapse to drug misuse may follow exposure to drug cues that elicit craving. The learned associations, or "emotional memories," that underlie responses to cues may be attenuated or erased by the β-adrenergic antagonist propranolol during a "reconsolidation window" shortly after the memories are reactivated by cues.
methodsWe evaluated the effects of propranolol on cue-induced drug cravings in healthy opioid-dependent individuals who used cocaine while receiving methadone maintenance (n = 33). Participants were asked to recall specific cocaine use and neutral events in an interview; these events were used to develop personalized auditory script/cue sets. Approximately 1 week later, propranolol (40 mg) or placebo (random assignment, double blind) was administered orally before presentation of the script/cue sets; the presentation of the script/cue sets were tested 1 week and 5 weeks after the propranolol/placebo session. Ongoing drug use was monitored via urine screens and self-report in twice-weekly visits.
resultsCue reactivity, as assessed by craving scales and physiological responses, was unexpectedly greater in the propranolol group than in the placebo group. This counterhypothesized group difference was present acutely during propranolol administration and seemed to persist (without reaching statistical significance) during the subsequent test sessions.
conclusionsOur results do not support the use of propranolol for cue-induced cocaine craving in opioid-maintained patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.