ArticlePloS one2015
23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 92 citations in OpenAlex.
- The SGLT2 inhibitor empagliflozin reduces tissue sodium content in patients with chronic heart failure: results from a placebo-controlled randomised trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Trial
- SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial.Cardiovascular diabetology · 2018 · on this mapTrial
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
- Estimation of skin sodium content viaMagma (New York, N.Y.) · 2026Article
- Preliminary evidence of extrarenal sodium storage in a large mammal: implications for comparative physiology and hypertension research : Running: Sodium storage in cattle.Pflugers Archiv : European journal of physiology · 2026Article
- Raman Investigation of Cardiac Tissues with Sodium-Induced High Stiffness.Molecules (Basel, Switzerland) · 2026Article
- Cardiovascular remodeling: key mechanisms and clinical implications linking sarcopenia and heart failure.Frontiers in medicine · 2026Review
- Sodium MRI of the skin using a surface coil to investigate and reduce signal loss and bias.Magnetic resonance in medicine · 2025Article
- Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging.Frontiers in cardiovascular medicine · 2025Article
- Targeting Sodium in Heart Failure.Journal of personalized medicine · 2024Review
- Sodium quantification in skeletal muscle: comparison between Cartesian gradient-echo and radial ultra-short echo timeEuropean radiology experimental · 2024Article
- Tissue Sodium Accumulation Induces Organ Inflammation and Injury in Chronic Kidney Disease.International journal of molecular sciences · 2023Review
- Understanding the Mechanisms and Treatment of Heart Failure: Quantitative Systems Pharmacology Models with a Focus on SGLT2 Inhibitors and Sex-Specific Differences.Pharmaceutics · 2023Review
- Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Journal of translational medicine · 2022Article
- Repeatability assessment of sodium (BMC musculoskeletal disorders · 2022Article
- Non-invasive assessment of tissue sodium content in patients with primary adrenal insufficiency.European journal of endocrinology · 2022Article
- Outcomes and predictors of skin sodium concentration in dialysis patients.Clinical kidney journal · 2022Article
- Skin Sodium and Blood Pressure Regulation.Electrolyte & blood pressure : E & BP · 2022Review
- Does Excess Tissue Sodium Storage Regulate Blood Pressure?Current hypertension reports · 2022Review
- Sodium-based osmotherapy for hyponatremia in acute decompensated heart failure.Heart failure reviews · 2022Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveNa+ can be stored in muscle and skin without commensurate water accumulation. The aim of this study was to assess Na+ and H2O in muscle and skin with MRI in acute heart failure patients before and after diuretic treatment and in a healthy cohort.
methodsNine patients (mean age 78 years; range 58-87) and nine age and gender-matched controls were studied. They underwent 23Na/1H-MRI at the calf with a custom-made knee coil. Patients were studied before and after diuretic therapy. 23Na-MRI gray-scale measurements of Na+-phantoms served to quantify Na+-concentrations. A fat-suppressed inversion recovery sequence was used to quantify H2O content.
resultsPlasma Na+-levels did not change during therapy. Mean Na+-concentrations in muscle and skin decreased after furosemide therapy (before therapy: 30.7±6.4 and 43.5±14.5 mmol/L; after therapy: 24.2±6.1 and 32.2±12.0 mmol/L; p˂0.05 and p˂0.01). Water content measurements did not differ significantly before and after furosemide therapy in muscle (p = 0.17) and only tended to be reduced in skin (p = 0.06). Na+-concentrations in calf muscle and skin of patients before and after diuretic therapy were significantly higher than in healthy subjects (18.3±2.5 and 21.1±2.3 mmol/L).
conclusions23Na-MRI shows accumulation of Na+ in muscle and skin in patients with acute heart failure. Diuretic treatment can mobilize this Na+-deposition; however, contrary to expectations, water and Na+-mobilization are poorly correlated.
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